11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 1.211 mg/kg
Remarks: (RTECS)
The value is given in analogy to the following substances: Diethyl ether
Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Acute toxicity estimate Oral - 1.211 mg/kg (ATE value derived from LD50/LC50 value)
LC50 Inhalation - Mouse - 4 h - 97,5 mg/l - vapor
Remarks: (RTECS)
The value is given in analogy to the following substances: Diethyl ether
Symptoms: mucosal irritations
LD50 Dermal - Rabbit - male - > 20.000 mg/kg (OECD Test Guideline 402)
Remarks: (ECHA)
The value is given in analogy to the following substances: Diethyl ether
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: Diethyl ether
Remarks: Dermatitis
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: Diethyl ether
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Remarks: The value is given in analogy to the following substances: Diethyl ether
Germ cell mutagenicity
Test Type: Micronucleus test
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 487
Result: negative
Remarks: The value is given in analogy to the following substances: Diethyl etherTest
Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: Diethyl etherTest
Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: Diethyl ether
Test Type: Micronucleus test
Species: Mouse
Cell type: Red blood cells (erythrocytes)
Application Route: Intraperitoneal
Method: OECD Test Guideline 474
Result: negative
Remarks: The value is given in analogy to the following substances: Diethyl ether
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Oral - May cause drowsiness or dizziness. - Central nervous system
Remarks: The value is given in analogy to the following substances: Diethyl ether
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rat - male and female - Oral - 13 Weeks - NOAEL (No observed adverse effect level) - 500 mg/kg - LOAEL (Lowest observed adverse effect level) - 2.000 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: Diethyl ether
Inhalation may provoke the following symptoms:
Cough, chest pain, Difficulty in breathing, Dizziness, Drowsiness, Contact with eyes can cause:, Redness, Provokes tears., Blurred vision, Prolonged or repeated exposure to skin causes defatting and dermatitis.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Narcotic!
After absorption:
Salivation ataxia (impaired locomotor coordination) inebriation
Unconsciousness
Coma
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Liver - Ingestion may provoke the following symptoms:, Irregularities - Based on Human
Evidence