Chemical Safety Data Sheet MSDS / SDS
DIETHYL MALONATE-2-13C
Revision Date:2026-03-22Revision Number:1
Product identifier
- Product name: DIETHYL MALONATE-2-13C
- CBnumber: CB9678938
- CAS: 67035-94-3
- Synonyms: DIETHYL MALONATE 13C;Diethyl malonate-2-<sup>13</sup>C
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
Hazard statements
H319 Causes serious eye irritation
Substance
- Product name: DIETHYL MALONATE-2-13C
- Synonyms: diethyl malonate-2-13C
- CAS: 67035-94-3
- MF: C7H12O4
- MW: 161.18
General advice
Show this safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Combustible. Vapours are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products
Carbon oxides
Specific extinguishing methods
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipbreathing ment for fire-fighters
In the event of fire, wear self-contained apparatus.
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up affected area.
Handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.
Storage
Further information on storage conditionsTightly closed.
Storage class
10, Combustible liquids
Recommended storage temperature
Recommended storage temperature see product label.
Ingredients with workplace control parameters
Contains no substances with occupational exposure limit values.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
Skin and body protection
Safety glasses
protective clothing
Hand protection
Material
butyl-rubber
Break through time
480 min
Glove thickness
0.7 mm
Protective index
Full contact
Manufacturer
Butoject® (KCL 898)
Material
Viton®
Break through time
120 min
Glove thickness
0.7 mm
Protective index
Splash contact
Manufacturer
Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Remarks
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D- 36124 Eichenzell, Internet: www.kcl.de).
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
Information on basic physicochemical properties
- SolubilityChloroform, Ethyl Acetate (Slightly)
- Physical stateOil
- Appearanceliquid
- ColorColourless
- OdorNo data available
- Odor ThresholdNo data available
- pHNo data available
- Melting point/ range-51 - -50 °C
Method: lit. - Boiling point/boiling range199 °C
Method: lit. - Flash point90.00 °C
Method: closed cup - Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Flammability (liquids)No data available
- Burning rateNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Lower explosion limit / Lower flammability limitNo data available
- Vapor pressure1 hPa (40.00 °C)
- Relative vapor density5.52
- Relative density1.054 g/mL at 25 °C
- Density1.054 g/cm3 (25 °C)
- Water solubilityNo data available
- Partition coefficient: n-octanol/waterNo data available
- Autoignition temperatureNo data available
- Decomposition temperatureNo data available
- Viscosity, dynamicNo data available
- Viscosity, kinematicNo data available
- Flow timeNo data available
- Explosive propertiesNot classified as explosive.
- Oxidizing propertiesnone
- Molecular weight161.15 g/mol
- Particle characteristics Particle sizeNo data available
Reactivity
Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Stable Violent reactions possible with: Bases Reducing agents Strong oxidizing agents acids
Conditions to avoid
Strong heating.
Incompatible materials
No data available
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male - 15,794 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: diethyl malonate
Inhalation: No data available
LD50 Dermal - Rabbit - male - > 16,960 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: diethyl malonate
Skin corrosion/irritation
Remarks: (ECHA)
The value is given in analogy to the following substances: diethyl malonate
Inhalation: No data available
LD50 Dermal - Rabbit - male - > 16,960 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: diethyl malonate
Skin - Rabbit
Result: slight irritation
Remarks: (ECHA)
The value is given in analogy to the following substances: diethyl malonate
Serious eye damage/eye irritation
Result: slight irritation
Remarks: (ECHA)
The value is given in analogy to the following substances: diethyl malonate
Eyes - Rabbit
Result: Causes serious eye irritation.
(US-EPA)
Remarks: (ECHA)
The value is given in analogy to the following substances: diethyl malonate
Respiratory or skin sensitization
Result: Causes serious eye irritation.
(US-EPA)
Remarks: (ECHA)
The value is given in analogy to the following substances: diethyl malonate
Maximisation Test - Humans
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: diethyl malo- nate
Germ cell mutagenicity
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: diethyl malo- nate
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: diethyl malo- nateTest Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: diethyl malo- nateTest Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: Regulation (EC) No. 440/2008, Annex, B.13/14 (Ames test)
Result: negative
Remarks: The value is given in analogy to the following substances: diethyl malo- nateCarcinogenicity
No data available
Reproductive toxicity
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: diethyl malo- nateTest Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: diethyl malo- nateTest Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: Regulation (EC) No. 440/2008, Annex, B.13/14 (Ames test)
Result: negative
Remarks: The value is given in analogy to the following substances: diethyl malo- nateCarcinogenicity
No data available
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - No observed adverse effect level - 300 mg/kg - Lowest observed adverse effect level - 1,000 mg/kg
Remarks: The value is given in analogy to the following substances: diethyl malo- nate
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately.
Cannot be excluded:
Stomach/intestinal disorders
Handle in accordance with good industrial hygiene and safety practice.
Remarks: The value is given in analogy to the following substances: diethyl malo- nate
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately.
Cannot be excluded:
Stomach/intestinal disorders
Handle in accordance with good industrial hygiene and safety practice.
Ecotoxicity
Components:
Toxicity to fishLC50 (Pimephales promelas (fathead minnow)): 15.4 mg/l End point: mortality Exposure time: 96 h Remarks: (IUCLID) The value is given in analogy to the following substances: The value is given in analogy to the following substances: diethyl malonate
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 202.3 mg/l Exposure time: 48 h Test Type: static test Method: Regulation (EC) No. 440/2008, Annex, C.2 GLP: yes Remarks: The value is given in analogy to the following substances: The value is given in analogy to the following substances: diethyl malonate
Toxicity to algae/aquatic plants
ErC50 (Desmodesmus subspicatus (green algae)): > 800 mg/l Exposure time: 72 h Test Type: static test GLP: yes Remarks: (ECHA) The value is given in analogy to the following substances: The value is given in analogy to the following substances: diethyl malonate
Persistence and degradability
Components:
Biodegradabilityaerobic Inoculum: activated sludge Concentration: 10.8 mg/l Result: Readily biodegradable. Biodegradation: 99 % Exposure time: 28 d Method: Directive 67/548/EEC Annex V, C.4.A. GLP: yes Remarks: The value is given in analogy to the following substances: The value is given in analogy to the following substances: diethyl malonate
Bioaccumulative potential
No data available
Mobility in soil
No data available
Other adverse effects
No data available
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Packing instruction (cargo aircraft) : Not applicable
Packing instruction (passenger aircraft) : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Packing instruction (cargo aircraft) : Not applicable
Packing instruction (passenger aircraft) : Not applicable
IMDG-Code
UN number : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
EmS Code : Not applicable
Marine pollutant : no
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
EmS Code : Not applicable
Marine pollutant : no
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations
JT/T 617
UN number : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Environmentally hazardous : no
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Environmentally hazardous : no
Special precautions for user
Not applicable
Catalogue of Hazardous Chemicals : This product is not listed in the catalogue of hazardous chemicals, but it meets the definition of hazardous chemicals and its principles of determination.
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
Not listed
Hazardous Chemicals for Priority Management
Not listed under SAWS
Catalogue of Specially Controlled Hazardous
Not listed Chemicals
List of Explosive Precursors
Not listed
Regulations on Labour Protection in Workplaces where Toxic Substances are Used
Catalogue of Highly Toxic Chemicals
Not listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number
B1A222214570
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Regulations on the Administration of Controlled Chemicals
List of Controlled Chemicals
Not listed
Regulations of Ozone Depleting Substances Management
List of Controlled Ozone Depleting Substances
Not listed
List of Controlled Ozone Depleting Substances Import and Export
Not listed
Environmental Protection Law
List of Priority Controlled Chemicals
Not listed
List of Key Controlled New Pollutants
Not listed
Full text of other abbreviations
AIIC - Australian Inventory of Industrial Chemicals
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonised System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organisation
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardisation
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
MERCOSUR - The Agreement for the Facilitation of the Transport of Dangerous Goods
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organisation for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonised System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organisation
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardisation
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
MERCOSUR - The Agreement for the Facilitation of the Transport of Dangerous Goods
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organisation for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.