11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - 730 mg/kg (OECD Test Guideline 401)
Remarks: The value is given in analogy to the following substances: Formic acid
LC50 Inhalation - Rat - male and female - 4 h - 7.85 mg/l - vapour (OECD Test Guideline 403)
Remarks: The value is given in analogy to the following substances: Formic acid
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Causes severe burns.
(OECD Test Guideline 404)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: Formic acid
Serious eye damage/eye irritation
Remarks: Causes serious eye damage.
conjunctivitis
Lacrimal irritation due to vapours.
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: Formic acid
Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: Formic ac- idTest Type: sister chromatid exchange assay
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 479
Result: negative
Remarks: The value is given in analogy to the following substances: Formic ac- idTest Type: sister chromatid exchange assay
Test system: Human lymphocytes
Metabolic activation: without metabolic activation
Method: OECD Test Guideline 479
Result: negative
Remarks: The value is given in analogy to the following substances: Formic ac- idTest Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: Formic ac- idTest Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: Formic acid
Test Type: gene mutation test
Species: Drosophila melanogaster
Application Route: Oral
Method: OECD Test Guideline 477
Result: negative
Remarks: The value is given in analogy to the following substances: Formic acid
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Corrosive to the respiratory tract.
The value is given in analogy to the following substances: Formic acid
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 52 Weeks - No observed adverse effect level - 400 mg/kg - Lowest observed adverse effect level - 2,000 mg/kg
Remarks: (in analogy to similar products)
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache,
Nausea, Vomiting
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.