Chemical Safety Data Sheet MSDS / SDS
GUANABENZ ACETATE
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: GUANABENZ ACETATE
- CBnumber: CB9491023
- CAS: 23256-50-0
- EINECS Number: 245-534-7
- Synonyms: WY-8678
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P501 Dispose of contents/container to..…
P405 Store locked up.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
Hazard statements
H301 Toxic if swalloed
Substance
- Product name: GUANABENZ ACETATE
- Synonyms: WY-8678
- CAS: 23256-50-0
- EC number: 245-534-7
- MF: C10H12Cl2N4O2
- MW: 291.13
General advice
Show this safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Hazardous combustion products
Carbon oxides Nitrogen oxides (NOx) Hydrogen chloride gas
Specific extinguishing methods
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Handling
Avoidance of contactStrong oxidizing agents
Storage
Further information on storage conditionsTightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class
6.1C, Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Recommended storage temperature
Recommended storage temperature see product label.
Ingredients with workplace control parameters
We are not aware of any national exposure limit.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type P3
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
Skin and body protection
Safety glasses
protective clothing
Hand protection
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Full contact
Manufacturer
(KCL 740 / Aldrich Z677272, Size M)
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Splash contact
Manufacturer
(KCL 740 / Aldrich Z677272, Size M)
Manufacturer
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
Remarks
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Hygiene measures
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Change contaminated clothing. Preventive skin protection recommended. Wash hands after working with substance.
Information on basic physicochemical properties
- SolubilityH2O: 11 mg/mL
- Physical statesolid
- Particle characteristics Particle sizeNo data available
- Molecular weight291.13 g/mol
- Oxidizing propertiesNo data available
- Explosive propertiesNo data available
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperatureNo data available
- Autoignition temperatureNo data available
- Partition coefficient: n-octanol/waterNo data available
- Water solubilitywater: 5mg/mL
- DensityNo data available
- Appearancesolid
- Relative densityNo data available
- Relative vapor densityNo data available
- Vapor pressureNo data available
- Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Burning rateNo data available
- Flammability (liquids)No data available
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash pointNo data available
- Boiling point/boiling rangeNo data available
- Melting point/ range191 - 192 °C
- pHNo data available
- Odor ThresholdNo data available
- OdorNo data available
- Colorwhite
Reactivity
No data available
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
No data available
Conditions to avoid
no information available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityAcute toxicity estimate Oral - 238 mg/kg (Calculation method)
LD50 Oral - Rat - 238 mg/kg
Remarks: Behavioral:General anesthetic.
Respiratory disorder
Kidney, Ureter, Bladder:Other changes.
(RTECS)
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
LD50 Oral - Rat - 238 mg/kg
Remarks: Behavioral:General anesthetic.
Respiratory disorder
Kidney, Ureter, Bladder:Other changes.
(RTECS)
Inhalation: No data available
Dermal: No data available
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
RTECS: MF0382000
Drowsiness, Weakness, Constipation., Nausea, Dizziness, Headache
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Drowsiness, Weakness, Constipation., Nausea, Dizziness, Headache
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Ecotoxicity
No data available
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Other adverse effects
No data available
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 2811
Proper shipping name : Toxic solid, organic, n.o.s.
(3-[(2,6-Dichlorophenyl)methylene]carbazamidine monoacetate)
Class : 6.1
Packing group : III
Labels : Division 6.1 - Toxic substances
Packing instruction (cargo aircraft) : 677
Packing instruction (passenger aircraft) : 670
Proper shipping name : Toxic solid, organic, n.o.s.
(3-[(2,6-Dichlorophenyl)methylene]carbazamidine monoacetate)
Class : 6.1
Packing group : III
Labels : Division 6.1 - Toxic substances
Packing instruction (cargo aircraft) : 677
Packing instruction (passenger aircraft) : 670
IMDG-Code
UN number : UN 2811
Proper shipping name : TOXIC SOLID, ORGANIC, N.O.S.
(3-[(2,6-Dichlorophenyl)methylene]carbazamidine monoacetate)
Class : 6.1
Packing group : III
Labels : 6.1
EmS Code : F-A, S-A
Marine pollutant : no
Proper shipping name : TOXIC SOLID, ORGANIC, N.O.S.
(3-[(2,6-Dichlorophenyl)methylene]carbazamidine monoacetate)
Class : 6.1
Packing group : III
Labels : 6.1
EmS Code : F-A, S-A
Marine pollutant : no
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations
JT/T 617
UN number : UN 2811
Proper shipping name : TOXIC SOLID, ORGANIC, N.O.S.
(3-[(2,6-Dichlorophenyl)methylene]carbazamidine monoacetate)
Class : 6.1
Packing group : III
Labels : 6.1
Environmentally hazardous : no
Proper shipping name : TOXIC SOLID, ORGANIC, N.O.S.
(3-[(2,6-Dichlorophenyl)methylene]carbazamidine monoacetate)
Class : 6.1
Packing group : III
Labels : 6.1
Environmentally hazardous : no
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals
Hazardous Chemicals for Priority Management
Not applicable under SAWS
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not applicable
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number
B1A222220151
Full text of other abbreviations
AIIC - Australian Inventory of Industrial Chemicals
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonised System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organisation
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardisation
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
MERCOSUR - The Agreement for the Facilitation of the Transport of Dangerous Goods
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organisation for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonised System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organisation
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardisation
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
MERCOSUR - The Agreement for the Facilitation of the Transport of Dangerous Goods
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organisation for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.