Chemical Safety Data Sheet MSDS / SDS

HEXADECYLTRIMETHOXYSILANE

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: HEXADECYLTRIMETHOXYSILANE
CBnumber: CB8711852
CAS: 16415-12-6
EINECS Number: 240-464-3
Synonyms: HEXADECYLTRIMETHOXYSILAN;HEXADECYLTRIMETHOXYSILANE

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordWarning

Precautionary statements

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

Hazard statements

H335 May cause respiratory irritation

H319 Causes serious eye irritation

H315 Causes skin irritation

SECTION 3: Composition/information on ingredients

Substance

Product name: HEXADECYLTRIMETHOXYSILANE
Synonyms: HEXADECYLTRIMETHOXYSILAN;HEXADECYLTRIMETHOXYSILANE
CAS: 16415-12-6
EC number: 240-464-3
MF: C19H42O3Si
MW: 346.62

SECTION 4: First aid measures

4.1 Description of first-aid measures

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration.

In case of skin contact

Wash off with soap and plenty of water.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

4.4 Notes to physician

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture

Carbon oxides silicon oxides
Combustible.

5.3 Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

NFPA 704

HEALTH	2	Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE	1	Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Avoid breathing vapors, mist or gas.
For personal protection see section 8.

6.2 Environmental precautions

No special environmental precautions required.

6.3 Methods and materials for containment and cleaning up

Keep in suitable, closed containers for disposal.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place.
Moisture sensitive.

Storage class

Storage class (TRGS 510): 10: Combustible liquids

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

Contains no substances with occupational exposure limit values.

8.2 Exposure controls

Appropriate engineering controls

General industrial hygiene practice.

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

No special environmental precautions required.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

a) Physical stateliquid
b) ColorColorless to Almost colorless
c) OdorNo data available
d) Melting point/freezing pointMelting point: 1.4 °C at 1,005 hPa - OECD Test Guideline 102
e) Initial boiling point and boiling range350 °C at 1,005 hPa - OECD Test Guideline 103
f) Flammability (solid, gas)No data available
g) Upper/lower flammability or explosive limitsNo data available
h) Flash point165 °C - closed cup
i) Autoignition temperature245 °C - DIN 51794
j) Decomposition temperatureNo data available
k) pHNo data available
l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available
m) Water solubility2μg/L at 20℃
n) Partition coefficient n-octanol/waterNo data available
o) Vapor pressure0Pa at 20℃
p) Density0.89 g/cm3 at 20.2 °C - OECD Test Guideline 109
Relative density0.89 g/mL at 20 °C (lit.)
q) Relative vapor densityNo data available
r) Particle characteristicsNo data available
s) Explosive propertiesNo data available
t) Oxidizing propertiesNo data available

9.2 Other safety information

No data available

SECTION 10: Stability and reactivity

10.1 Chemical stability

Stable under recommended storage conditions.

10.2 Possibility of hazardous reactions

No data available

10.3 Conditions to avoid

No data available

10.4 Incompatible materials

No data available

10.5 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 423)
Inhalation: No data available
LD50 Dermal - Rabbit - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: trimethoxyoctadecylsilane

Skin corrosion/irritation

Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)

Respiratory or skin sensitization

Buehler Test - Guinea pig
Result: negative (OECD Test Guideline 406)

Germ cell mutagenicity

Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative

Carcinogenicity