Chemical Safety Data Sheet MSDS / SDS
Nicotine
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: Nicotine
- CBnumber: CB5293753
- CAS: 54-11-5
- EINECS Number: 200-193-3
- Synonyms: Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-;(?)-Nicotine
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P273 Avoid release to the environment.
P262 Do not get in eyes, on skin, or on clothing.
Hazard statements
H315 Causes skin irritation
H318 Causes serious eye damage
H411 Toxic to aquatic life with long lasting effects
Substance
- Product name: Nicotine
- Synonyms: Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-;(?)-Nicotine
- CAS: 54-11-5
- EC number: 200-193-3
- MF: C10H14N2
- MW: 162.23
Description of first aid measures
General information
Immediately remove any clothing soiled by the product.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
After inhalation
Supply fresh air or oxygen; call for doctor.
In case of unconsciousness place patient stably in side position for transportation.
In case of unconsciousness place patient stably in side position for transportation.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
After eye contact
Rinse opened eye for several minutes under running water. Then consult a doctor.
After swallowing
Do not induce vomiting; immediately call for medical help.
Information for doctor
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
Extinguishing media
Suitable extinguishing agents
CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
Special hazards arising from the substance or mixture
No further relevant information available.
Advice for firefighters
Protective equipment
Mouth respiratory protective device.
NFPA 704
3
1
0
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Not required.
Environmental precautions
Inform respective authorities in case of seepage into water course or sewage system.
Dilute with plenty of water.
Do not allow to enter sewers/ surface or ground water.
Dilute with plenty of water.
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Protective Action Criteria for Chemicals
PAC-1
1.5 mg/m³
PAC-2
3.5 mg/m³
PAC-3
35 mg/m³
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 8 for information on personal protection equipment.
Handling
Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.
Open and handle receptacle with care.
Information about protection against explosions and fires
Keep respiratory protective device available.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
No special requirements.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
Keep receptacle tightly sealed.
Specific end use(s)
No further relevant information available.
Additional information about design of technical systems
No further data; see section 7.
Control parameters
Components with limit values that require monitoring at the workplace:
| 54-11-5 (−)-Nicotine | |
|---|---|
| PEL | Long-term value: 0.5 mg/m³ Skin |
| REL | Long-term value: 0.5 mg/m³ Skin |
| TLV | Long-term value: 0.5 mg/m³ Skin |
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Breathing equipment
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
Protection of hands
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Goggles recommended during refilling.
Information on basic physicochemical properties
- Water solubilityMISCIBLE
- Vapour pressure0.06 hPa (20 °C)
- Upper/lower flammability or explosive limits0.7-4%(V)
- Other informationNo information available
- SOLUBILITYDMF: 50 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml
- KinematicNot determined.
- DynamicNot determined.
- Partition coefficient (n-octanol/water)Not determined.
- WaterFully miscible.
- Solubility in / Miscibility withethanol: 50 mg/mL
- Evaporation RateNot determined.
- Vapor DensityNot determined.
- Relative Density1.010 g/mL at 20 °C(lit.)
- Density at 20 °C (68 °F)1.0092 g/cm³ (8.42177 lbs/gal)
- Vapor Pressure at 50 °C (122 °F)0.36 hPa (0.3 mm Hg)
- Vapor Pressure at 20 °C (68 °F)0.056 hPa (0 mm Hg)
- Explosion limitsLower: 0.7 Vol %
Upper: 4 Vol % - Danger of explosionProduct does not present an explosion hazard.
- Ignition temperatureNot determined.
- Decomposition temperatureNot determined.
- Auto igniting240 °C (464 °F)
- Flammability (solid,gas)Not applicable.
- Flash point95 °C (203 °F)
- Boiling point/Boiling range247 °C (476.6 °F)
- Melting point/Melting range-79 °C (-110.2 °F)
- pH10.2 (8.1g/l, H2O, 20°C)
- Odor ThresholdNot determined.
- Molecular Weight162.2 g/mol
- Structural FormulaC10H14N2
- OdorCharacteristic
- Coloryellow
- Physical Stateoil
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
No further relevant information available.
Hazardous decomposition products
No dangerous decomposition products known.
RTECS Number
QS5250000
Information on toxicological effects
Acute toxicity
LD/LC50 values that are relevant for classification:
| Route | Endpoint | Value |
|---|---|---|
| Oral | LD50 | 5 mg/kg (ATE) ECHA |
| Dermal | LD50 | 70 mg/kg (ATE) ECHA |
| Inhalative | LC50/4 h | 0.19 mg/l (ATE) ECHA |
Primary irritant effect
on the skin
No irritant effect.
on the eye
No irritating effect.
Sensitization
No sensitizing effects known.
Additional toxicological information
Carcinogenic categories
IARC (International Agency for Research on Cancer)
Substance is not listed.
NTP (National Toxicology Program)
Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Behavior in environmental systems
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Ecotoxical effects
Remark
Toxic for fish
Additional ecological information
General notes
Water hazard class 3 (Self-assessment) extremely hazardous for water
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.
Also poisonous for fish and plankton in water bodies.
Toxic for aquatic organisms
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.
Also poisonous for fish and plankton in water bodies.
Toxic for aquatic organisms
Results of PBT and vPvB assessment
PBT
Not applicable.
vPvB
Not applicable.
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
No further relevant information available.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
Recommended cleansing agent
Water, if necessary with cleansing agents.
UN-Number
DOT, IMDG, IATA UN1654
UN proper shipping name
DOT, IATA Nicotine
IMDG NICOTINE
IMDG NICOTINE
Transport hazard class(es)
DOTClass: 6.1 Toxic substances
Label: 6.1
IMDG
Label: 6.1
Class: 6.1 Toxic substances
Label: 6.1
IATA
Label: 6.1
Class: 6.1 Toxic substances
Label: 6.1
Label: 6.1
Packing group
DOT, IMDG, IATA II
Environmental hazards
Environmentally hazardous substance, liquid
Marine pollutant
Symbol (fish and tree)
Special precautions for user
Warning: Toxic substances
Hazard identification number (Kemler code)
60
EMS Number
F-A,S-A
Stowage Category
A
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information
DOT:
Quantity limitations
On passenger aircraft/rail: 5 L
On cargo aircraft only: 60 L
On cargo aircraft only: 60 L
IMDG:
Limited quantities (LQ)
100 ml
Excepted quantities (EQ)
Code: E4
Maximum net quantity per inner packaging: 1 ml
Maximum net quantity per outer packaging: 500 ml
Maximum net quantity per inner packaging: 1 ml
Maximum net quantity per outer packaging: 500 ml
IATA:
Remarks
When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
UN "Model Regulation"
UN 1654 NICOTINE, 6.1, II, ENVIRONMENTALLY
HAZARDOUS
HAZARDOUS
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | Substance is listed. |
| Section 313 (Specific toxic chemical listings): | Substance is listed. |
| TSCA (Toxic Substances Control Act): | ACTIVE |
| Hazardous Air Pollutants: | Substance is not listed. |
Proposition 65
| Chemicals known to cause cancer: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for females: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for males: | Substance is not listed. |
| Chemicals known to cause developmental toxicity: | Substance is listed. |
Chemicals known to cause cancer
Substance is not listed.
Chemicals known to cause reproductive toxicity for females
Substance is not listed.
Chemicals known to cause reproductive toxicity for males
Substance is not listed.
Chemicals known to cause developmental toxicity
Substance is listed.
Carcinogenic categories
| EPA (Environmental Protection Agency): | Substance is not listed. |
TLV (Threshold Limit Value)
Substance is not listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute Toxicity - Oral 2: Acute toxicity – Category 2
Aquatic Chronic 2: Hazardous to the aquatic environment - long-term aquatic hazard – Category 2
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute Toxicity - Oral 2: Acute toxicity – Category 2
Aquatic Chronic 2: Hazardous to the aquatic environment - long-term aquatic hazard – Category 2
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.