11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 854 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Dyspnea.
(RTECS)
Acute toxicity estimate Inhalation - 1.6 mg/l - dust/mist (Expert judgement)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Symptoms: Possible damages:, May cause irritation of respiratory tract.
Acute toxicity estimate Dermal - 1,100 mg/kg (Expert judgement)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin corrosion/irritation
Skin - reconstructed human epidermis (RhE)
Result: No skin irritation - 5 min (Regulation (EC) No. 440/2008, Annex, B.46)
Remarks: The value is given in analogy to the following substances: sodium thio- cyanate
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Irreversible effects on the eye (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: sodium thio- cyanate
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Remarks: The value is given in analogy to the following substances: sodium thio- cyanate
Germ cell mutagenicity
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: sodium thio- cyanateTest Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: Ammonium thiocyanateTest Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: sodium thio- cyanateCarcinogenicity
No data available
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 92 d - No observed adverse effect level - 20 mg/kg
Remarks: The value is given in analogy to the following substances: Ammonium thiocyanate
RTECS: XL1925000
Nausea, Headache, Vomiting
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption: agitation, spasms ataxia (impaired locomotor coordination)
Systemic effects:
CNS disorders cardiovascular disorders
After long-term exposure to the chemical:
Changes in the blood count
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.