Chemical Safety Data Sheet MSDS / SDS
PROPIONIC ACID-D6
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: PROPIONIC ACID-D6
- CBnumber: CB1430895
- CAS: 19448-61-4
- Synonyms: propanoic acid-d6;Propanoic-d5 acid-d
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P240 Ground/bond container and receiving equipment.
P233 Keep container tightly closed.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H335 May cause respiratory irritation
H314 Causes severe skin burns and eye damage
H226 Flammable liquid and vapour
Substance
- Product name: PROPIONIC ACID-D6
- Synonyms: propanoic acid-d6;Propanoic-d5 acid-d
- CAS: 19448-61-4
- MF: C3D6O2
- MW: 80.12
4.1 Description of first-aid measures
General adviceFirst aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
Remove contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaWater Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air at elevated temperatures.
Development of hazardous combustion gases or vapours possible in the event of fire.
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air at elevated temperatures.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
3
2
1
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsKeep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.
Storage class
Storage class (TRGS 510): 3: Flammable liquids
8.1 Control parameters
Ingredients with workplace control parameters| ['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis'] | ['Propionic acid-d6', '19448-61-\n4', 'PC-TWA', '30 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] |
|---|
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.4 mm
Break through time: 120 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
Body Protection
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.4 mm
Break through time: 120 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorNo data available
- c) OdorNo data available
- d) Melting point/freezing pointMelting point/range: -24 - -23 °C - lit.
- e) Initial boiling point and boiling range141 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point54 °C - closed cup
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityNo data available
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density1.072 g/mL at 25 °C 1.072 g/cm3 at 25 °C
- Relative density1.072 g/mL at 25 °C
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Exothermic reaction with:
Oxidizing agents
Reducing agents alkalines
Risk of ignition or formation of inflammable gases or vapours with:
Iron
Zinc magnesium
Lead
Oxidizing agents
Reducing agents alkalines
Risk of ignition or formation of inflammable gases or vapours with:
Iron
Zinc magnesium
Lead
10.3 Conditions to avoid
Heating.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male and female - 3,455.1 mg/kg (OECD Test Guideline 401)
Remarks: The value is given in analogy to the following substances: propionic acid
LC50 Inhalation - Rat - male and female - 1 h - > 19.7 mg/l - vapor (OECD Test Guideline 403)
Remarks: The value is given in analogy to the following substances: propionic acid
LD50 Dermal - Rat - female - 3,235 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: propionic acid
Skin corrosion/irritation
Remarks: The value is given in analogy to the following substances: propionic acid
LC50 Inhalation - Rat - male and female - 1 h - > 19.7 mg/l - vapor (OECD Test Guideline 403)
Remarks: The value is given in analogy to the following substances: propionic acid
LD50 Dermal - Rat - female - 3,235 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: propionic acid
Skin - Rabbit
Result: Corrosive
Remarks: (ECHA)
The value is given in analogy to the following substances: propionic acid
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Serious eye damage/eye irritation
Result: Corrosive
Remarks: (ECHA)
The value is given in analogy to the following substances: propionic acid
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Eyes - Rabbit
Result: Causes serious eye damage. - 24 h
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: propionic acid
Respiratory or skin sensitization
Result: Causes serious eye damage. - 24 h
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: propionic acid
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Test Type: sister chromatid exchange assay
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 479
Result: negative
Remarks: The value is given in analogy to the following substances: propionic acidTest
Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: propionic acid
Test Type: Micronucleus test
Species: Chinese hamster
Cell type: Bone marrow
Application Route: Intraperitoneal
Method: OECD Test Guideline 474
Result: negative
Remarks: The value is given in analogy to the following substances: propionic acid
Carcinogenicity
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 479
Result: negative
Remarks: The value is given in analogy to the following substances: propionic acidTest
Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: propionic acid
Test Type: Micronucleus test
Species: Chinese hamster
Cell type: Bone marrow
Application Route: Intraperitoneal
Method: OECD Test Guideline 474
Result: negative
Remarks: The value is given in analogy to the following substances: propionic acid
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Respiratory Tract
Remarks: The value is given in analogy to the following substances: propionic acid
Specific target organ toxicity - repeated exposure
Remarks: The value is given in analogy to the following substances: propionic acid
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Mouse - female - Dermal - 90 Days - LOAEL (Lowest observed adverse effect level) - 136.9 mg/kg
Remarks: The value is given in analogy to the following substances: propionic acid
May cause an asthmatic-like bronchitis., Nausea, Dizziness, Headache, Blood disorders,
May cause irritation to eyes and respitatory passages to workers briefly exposed to high concentrations
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Liver - Irregularities - Based on Human Evidence
Remarks: The value is given in analogy to the following substances: propionic acid
May cause an asthmatic-like bronchitis., Nausea, Dizziness, Headache, Blood disorders,
May cause irritation to eyes and respitatory passages to workers briefly exposed to high concentrations
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Liver - Irregularities - Based on Human Evidence
12.1 Toxicity
Toxicity to fish static test LC50 - Leuciscus idus (Golden orfe) - > 10,000 mg/l - 96 h (DIN 38412)
Remarks: The value is given in analogy to the following substances: calcium dipropionate
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 500 mg/l - 48 h and other aquatic (Directive 67/548/EEC, Annex V, C.2.) invertebrates Remarks: The value is given in analogy to the following substances: calcium dipropionate
Toxicity to algae static test EC50 - Desmodesmus subspicatus (green algae) - > 500 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: calcium dipropionate
Toxicity to bacteria EC50 - Pseudomonas putida - 60 mg/l - 17 h (DIN 38412)
Remarks: (IUCLID)
The value is given in analogy to the following substances: propionic acid
Remarks: The value is given in analogy to the following substances: calcium dipropionate
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 500 mg/l - 48 h and other aquatic (Directive 67/548/EEC, Annex V, C.2.) invertebrates Remarks: The value is given in analogy to the following substances: calcium dipropionate
Toxicity to algae static test EC50 - Desmodesmus subspicatus (green algae) - > 500 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: calcium dipropionate
Toxicity to bacteria EC50 - Pseudomonas putida - 60 mg/l - 17 h (DIN 38412)
Remarks: (IUCLID)
The value is given in analogy to the following substances: propionic acid
12.2 Persistence and degradability
Biodegradability
Result: - Readily biodegradable.
Result: - Readily biodegradable.
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
Biological effects:
Harmful effect due to pH shift.
Discharge into the environment must be avoided.
Harmful effect due to pH shift.
Discharge into the environment must be avoided.
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 3463
IMDG: 3463
IATA-DGR: 3463
IMDG: 3463
IATA-DGR: 3463
14.2 UN proper shipping name
ADR/RID: PROPIONIC ACID
IMDG: PROPIONIC ACID
IATA-DGR: Propionic acid
IMDG: PROPIONIC ACID
IATA-DGR: Propionic acid
14.3 Transport hazard class(es)
ADR/RID: 8 (3)
IMDG: 8 (3)
IATA-DGR: 8 (3)
IMDG: 8 (3)
IATA-DGR: 8 (3)
14.4 Packaging group
ADR/RID: II
IMDG: II
IATA-DGR: II
IMDG: II
IATA-DGR: II
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222223778
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222223778
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.