Chemical Safety Data Sheet MSDS / SDS
Revision Date:2026-03-21Revision Number:1
Product identifier
- CAS: 57-55-6
- EINECS Number: 200-338-0
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P405 Store locked up.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P501 Dispose of contents/container to..…
Hazard statements
H372 Causes damage to organs through prolonged or repeated exposure
H370 Causes damage to organs
Substance
- Product name: Propylene glycol
- Synonyms: 1,2-PROPANEDIOL;PG
- CAS: 57-55-6
- EC number: 200-338-0
- MF: C3H8O2
- MW: 76.09
4.1 Description of first-aid measures
If inhaledAfter inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
5.1 Extinguishing media
Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
5.4 Further information
Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
0
1
0
| HEALTH | 0 | Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed.
Hygroscopic. Light sensitive.
Storage class
Hygroscopic. Light sensitive.
Storage class (TRGS 510): 10: Combustible liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
8.1 Control parameters
Ingredients with workplace control parameters8.2 Exposure controls
Personal protective equipmentEye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Respiratory protection
Recommended Filter type: Filter A-(P2)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) Colorcolorless
- c) Odorat 100.00 %. odorless very slight alcoholic
- d) Melting point/freezing pointMelting point/ range: -60 °C
- e) Initial boiling point and boiling range187 °C
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsUpper explosion limit: 12,5 %(V)
Lower explosion limit: 2,6 %(V) - h) Flash point104 °C - closed cup - Regulation (EC) No. 440/2008, Annex, A.9
- i) Autoignition temperature> 400 °C at > 1.000,1 - < 1.014,4 hPa
- j) Decomposition temperatureNo data available
- k) pH6-8 (100g/l, H2O, 20℃)
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: 12,78 mPa.s at 45 °C - m) Water solubilitymiscible at 20 °C - Regulation (EC) No. 440/2008, Annex, A.6completely
- n) Partition coefficient n-octanol/waterPow: 0,085; log Pow: -1,07 at 20,5 °C - Regulation (EC) No.
440/2008, Annex, A.8 - Bioaccumulation is not expected. - o) Vapor pressure0,2 hPa at 25 °C - Regulation (EC) No. 440/2008, Annex, A.4
- p) Density1,036 g/mL at 25 °C
- Relative density1,03 at 20 °C - Regulation (EC) No. 440/2008, Annex, A.3
- q) Relative vapor density2.62 (vs air)
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
9.2 Other safety information
Surface tension71,6 mN/m at 1,01g/l at 21,5 °C - Surface tension
10.1 Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
increased reactivity with:
Oxidizing agents
Acid anhydrides
Acid chlorides various plastics
Violent reactions possible with:
Strong oxidizing agents
Oxidizing agents
Acid anhydrides
Acid chlorides various plastics
Violent reactions possible with:
Strong oxidizing agents
10.4 Conditions to avoid
Exposure to moisture.
Strong heating.
Strong heating.
10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male and female - 22.000 mg/kg
Remarks: (ECHA)
Inhalation: No data available
LD50 Dermal - Rabbit - > 2.000 mg/kg
Remarks: (ECHA)
Skin corrosion/irritation
Remarks: (ECHA)
Inhalation: No data available
LD50 Dermal - Rabbit - > 2.000 mg/kg
Remarks: (ECHA)
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Result: No eye irritation (OECD Test Guideline 405)
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Result: negative (OECD Test Guideline 406)
Test Type: Chromosome aberration test in vitro
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal
Result: negative
Remarks: (ECHA)
Test Type: Chromosome aberration test in vitro
Species: Rat
Cell type: Bone marrow
Application Route: Oral
Result: negative
Remarks: (ECHA)
Test Type: dominant lethal test
Species: Rat
Application Route: Oral
Result: negative
Remarks: (ECHA)
Carcinogenicity
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal
Result: negative
Remarks: (ECHA)
Test Type: Chromosome aberration test in vitro
Species: Rat
Cell type: Bone marrow
Application Route: Oral
Result: negative
Remarks: (ECHA)
Test Type: dominant lethal test
Species: Rat
Application Route: Oral
Result: negative
Remarks: (ECHA)
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting propertiesProduct:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rat - male - Oral - 2 yr - NOAEL (No observed adverse effect level) - 1.700 mg/kg
Remarks: (ECHA)
RTECS: TY2000000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately.
Handle in accordance with good industrial hygiene and safety practice.
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rat - male - Oral - 2 yr - NOAEL (No observed adverse effect level) - 1.700 mg/kg
Remarks: (ECHA)
RTECS: TY2000000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately.
Handle in accordance with good industrial hygiene and safety practice.
12.1 Toxicity
Toxicity to fish static test LC50 - Oncorhynchus mykiss (rainbow trout) - 40.613 mg/l - 96 h
Remarks: (ECHA)
Toxicity to daphnia static test LC50 - Ceriodaphnia dubia (water flea) - 18.340 mg/l - 48 and other aquatic h invertebrates (US-EPA)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - 19.000 mg/l - 96 h (OECD Test Guideline 201)
Toxicity to bacteria NOEC - Pseudomonas putida - > 20.000 mg/l - 18 h
Remarks: (ECHA)
Toxicity to daphnia semi-static test NOEC - Ceriodaphnia (water flea) - 29.000 mg/l - 7 and other aquatic d invertebrates(Chronic (US-EPA) toxicity)
Remarks: (ECHA)
Toxicity to daphnia static test LC50 - Ceriodaphnia dubia (water flea) - 18.340 mg/l - 48 and other aquatic h invertebrates (US-EPA)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - 19.000 mg/l - 96 h (OECD Test Guideline 201)
Toxicity to bacteria NOEC - Pseudomonas putida - > 20.000 mg/l - 18 h
Remarks: (ECHA)
Toxicity to daphnia semi-static test NOEC - Ceriodaphnia (water flea) - 29.000 mg/l - 7 and other aquatic d invertebrates(Chronic (US-EPA) toxicity)
12.2 Persistence and degradability
Biodegradability aerobic Dissolved organic carbon (DOC) - Exposure time 28 d
Result: 98,3 % - Readily biodegradable.
(OECD Test Guideline 301F)
Result: 98,3 % - Readily biodegradable.
(OECD Test Guideline 301F)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
12.7 Other adverse effects
Biological effects:
When discharged properly, no impairments in the function of adapted biological wastewater treatment plants are to be expected.
Stability in water - 2,3 yr
Remarks: reaction with hydroxyl radicals(IUCLID)
When discharged properly, no impairments in the function of adapted biological wastewater treatment plants are to be expected.
Stability in water - 2,3 yr
Remarks: reaction with hydroxyl radicals(IUCLID)
14.1 UN number
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA: no
IMDG Marine pollutant: no
IATA: no
14.6 Special precautions for user
No data available
Further information: Not classified as dangerous in the meaning of transport regulations.
Further information: Not classified as dangerous in the meaning of transport regulations.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
1907/2006.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways
ADR - Agreement concerning the International Carriage ofDangerous Goods by Road
AIIC - Australian Inventory of Industrial Chemicals
ASTM -American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen,Mutagen or Reproductive Toxicant
DIN - Standard of the German Institute forStandardisation
DSL - Domestic Substances List (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS -Emergency Schedule
ENCS - Existing and New Chemical Substances (Japan)
ErCx -Concentration associated with x% growth rate response
GHS - Globally HarmonizedSystem
GLP - Good Laboratory Practice
IARC - International Agency for Research onCancer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 - Half maximal inhibitory concentration
ICAO - International Civil Aviation Organization
IECSC - Inventory of Existing Chemical Substances in China
IMDG - InternationalMaritime Dangerous Goods
IMO - International Maritime Organization
ISHL - IndustrialSafety and Health Law (Japan)
ISO - International Organisation for Standardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concentration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pollution from Ships
n.o.s. -Not Otherwise Specified
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Effect Level
NOELR - No Observable Effect LoadingRate
NZIoC - New Zealand Inventory of Chemicals
OECD - Organization for EconomicCo-operation and Development
OPPTS - Office of Chemical Safety and PollutionPrevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - PhilippinesInventory of Chemicals and Chemical Substances
(Q)SAR - (Quantitative) StructureActivity Relationship
REACH - Regulation (EC) No 1907/2006 of the EuropeanParliament and of the Council concerning the Registration, Evaluation, Authorisation andRestriction of Chemicals
RID - Regulations concerning the International Carriage ofDangerous Goods by Rail
SADT - Self-Accelerating Decomposition Temperature
SDS -Safety Data Sheet
TCSI - Taiwan Chemical Substance Inventory
TECI - ThailandExisting Chemicals Inventory
TSCA - Toxic Substances Control Act (United States)
UN - United Nations
UNRTDG - United Nations Recommendations on the Transport ofDangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
ADR - Agreement concerning the International Carriage ofDangerous Goods by Road
AIIC - Australian Inventory of Industrial Chemicals
ASTM -American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen,Mutagen or Reproductive Toxicant
DIN - Standard of the German Institute forStandardisation
DSL - Domestic Substances List (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS -Emergency Schedule
ENCS - Existing and New Chemical Substances (Japan)
ErCx -Concentration associated with x% growth rate response
GHS - Globally HarmonizedSystem
GLP - Good Laboratory Practice
IARC - International Agency for Research onCancer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 - Half maximal inhibitory concentration
ICAO - International Civil Aviation Organization
IECSC - Inventory of Existing Chemical Substances in China
IMDG - InternationalMaritime Dangerous Goods
IMO - International Maritime Organization
ISHL - IndustrialSafety and Health Law (Japan)
ISO - International Organisation for Standardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concentration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pollution from Ships
n.o.s. -Not Otherwise Specified
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Effect Level
NOELR - No Observable Effect LoadingRate
NZIoC - New Zealand Inventory of Chemicals
OECD - Organization for EconomicCo-operation and Development
OPPTS - Office of Chemical Safety and PollutionPrevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - PhilippinesInventory of Chemicals and Chemical Substances
(Q)SAR - (Quantitative) StructureActivity Relationship
REACH - Regulation (EC) No 1907/2006 of the EuropeanParliament and of the Council concerning the Registration, Evaluation, Authorisation andRestriction of Chemicals
RID - Regulations concerning the International Carriage ofDangerous Goods by Rail
SADT - Self-Accelerating Decomposition Temperature
SDS -Safety Data Sheet
TCSI - Taiwan Chemical Substance Inventory
TECI - ThailandExisting Chemicals Inventory
TSCA - Toxic Substances Control Act (United States)
UN - United Nations
UNRTDG - United Nations Recommendations on the Transport ofDangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.