Chemical Safety Data Sheet MSDS / SDS
TRIS-D11
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: TRIS-D11
- CBnumber: CB2310110
- CAS: 202656-13-1
- Synonyms: Tris (D??, 98%);Tris-d11 solution
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P271 Use only outdoors or in a well-ventilated area.
P264 Wash skin thouroughly after handling.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Hazard statements
H335 May cause respiratory irritation
H319 Causes serious eye irritation
H315 Causes skin irritation
Substance
- Product name: TRIS-D11
- Synonyms: Tris (D??, 98%);Tris-d11 solution
- CAS: 202656-13-1
- MF: C4D11NO3
- MW: 132.2
4.1 Description of first-aid measures
General adviceConsult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Consult a physician.
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
5.1 Extinguishing media
Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Nitrogen oxides (NOx)
Nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols.
Advice on protection against fire and explosion
Provide appropriate exhaust ventilation at places where dust is formed.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsKeep container tightly closed in a dry and well-ventilated place. Store in cool place.
Store under inert gas. hygroscopic
Storage class
Store under inert gas. hygroscopic
Storage class (TRGS 510): 11: Combustible Solids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
8.1 Control parameters
Ingredients with workplace control parameters8.2 Exposure controls
Personal protective equipmentEye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as
NIOSH (US) or EN 166(EU).
NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Body Protection
Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU
EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical statesolid
- b) ColorWhite to off-white
- c) OdorNo data available
- d) Melting point/freezing pointMelting point/range: 162 - 165 °C
- e) Initial boiling point and boiling range219 - 220 °C
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash pointNo data available
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityNo data available
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density1.137 g/mL at 25 °C
- Relative density1.137 g/mL at 25 °C
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesNo data available
9.2 Other safety information
No data available
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - female - > 5.000 mg/kg (OECD Test Guideline 425)
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethane
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 5.000 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethane
Skin corrosion/irritation
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethane
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 5.000 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethane
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethane
Serious eye damage/eye irritation
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethane
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethane
Respiratory or skin sensitization
Result: No eye irritation (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethane
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethaneTest Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethaneCarcinogenicity
No data available
Reproductive toxicity
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethaneTest Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethaneCarcinogenicity
No data available
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting propertiesProduct:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rabbit - male and female - 28 d - LOAEL (Lowest observed adverse effect level) - 500 mg/kg
Remarks: Subacute toxicity
The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethaneThe value is given in analogy to the following substances:
Repeated dose toxicity - Rat - male and female - Oral - 90 d - NOAEL (No observed adverse effect level) - 250 mg/kg - LOAEL (Lowest observed adverse effect level) - 1.000 mg/kg
Remarks: Subchronic toxicity
The value is given in analogy to the following substances:
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After swallowing of large amounts:
Diarrhea
Nausea
Vomiting
Convulsions
The following applies to aliphatic amines in general: irritations after contact with eyes and skin. Mucosal irritations, coughing, and dyspnoea after inhalation.
This substance should be handled with particular care.
Under given conditions, contact with nitrites or nitric acid can lead to the formation of nitrosamines, which have shown themselves to be carcinogenic in animal experiments.
However, when the product is handled appropriately, hazardous effects are unlikely to occur.
Handle in accordance with good industrial hygiene and safety practice.
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rabbit - male and female - 28 d - LOAEL (Lowest observed adverse effect level) - 500 mg/kg
Remarks: Subacute toxicity
The value is given in analogy to the following substances: Tris(hydroxymethyl) aminomethaneThe value is given in analogy to the following substances:
Repeated dose toxicity - Rat - male and female - Oral - 90 d - NOAEL (No observed adverse effect level) - 250 mg/kg - LOAEL (Lowest observed adverse effect level) - 1.000 mg/kg
Remarks: Subchronic toxicity
The value is given in analogy to the following substances:
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After swallowing of large amounts:
Diarrhea
Nausea
Vomiting
Convulsions
The following applies to aliphatic amines in general: irritations after contact with eyes and skin. Mucosal irritations, coughing, and dyspnoea after inhalation.
This substance should be handled with particular care.
Under given conditions, contact with nitrites or nitric acid can lead to the formation of nitrosamines, which have shown themselves to be carcinogenic in animal experiments.
However, when the product is handled appropriately, hazardous effects are unlikely to occur.
Handle in accordance with good industrial hygiene and safety practice.
12.1 Toxicity
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 980 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates Remarks: The value is given in analogy to the following substances:
Tris(hydroxymethyl)aminomethane
Toxicity to bacteria static test EC50 - activated sludge - > 1.000 mg/l - 3 h (OECD Test Guideline 209)
Remarks: The value is given in analogy to the following substances:
Tris(hydroxymethyl)aminomethane
Tris(hydroxymethyl)aminomethane
Toxicity to bacteria static test EC50 - activated sludge - > 1.000 mg/l - 3 h (OECD Test Guideline 209)
Remarks: The value is given in analogy to the following substances:
Tris(hydroxymethyl)aminomethane
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 97,1 % - Readily biodegradable.
(OECD Test Guideline 301F)
Remarks: The value is given in analogy to the following substances:
Tris(hydroxymethyl)aminomethane
Result: 97,1 % - Readily biodegradable.
(OECD Test Guideline 301F)
Remarks: The value is given in analogy to the following substances:
Tris(hydroxymethyl)aminomethane
12.3 Bioaccumulative potential
No bioaccumulation is to be expected (log Pow <= 4).
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
12.7 Other adverse effects
Discharge into the environment must be avoided.
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
Contaminated packaging
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
Dispose of as unused product.
14.1 UN number
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA: -
IMDG: -
IATA: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA: no
IMDG Marine pollutant: no
IATA: no
14.6 Special precautions for user
No data available
Further information: Not classified as dangerous in the meaning of transport regulations.
Further information: Not classified as dangerous in the meaning of transport regulations.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
1907/2006.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways
ADR - Agreement concerning the International Carriage ofDangerous Goods by Road
AIIC - Australian Inventory of Industrial Chemicals
ASTM -American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen,Mutagen or Reproductive Toxicant
DIN - Standard of the German Institute forStandardisation
DSL - Domestic Substances List (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS -Emergency Schedule
ENCS - Existing and New Chemical Substances (Japan)
ErCx -Concentration associated with x% growth rate response
GHS - Globally HarmonizedSystem
GLP - Good Laboratory Practice
IARC - International Agency for Research onCancer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 - Half maximal inhibitory concentration
ICAO - International Civil Aviation Organization
IECSC - Inventory of Existing Chemical Substances in China
IMDG - InternationalMaritime Dangerous Goods
IMO - International Maritime Organization
ISHL - IndustrialSafety and Health Law (Japan)
ISO - International Organisation for Standardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concentration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pollution from Ships
n.o.s. -Not Otherwise Specified
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Effect Level
NOELR - No Observable Effect LoadingRate
NZIoC - New Zealand Inventory of Chemicals
OECD - Organization for EconomicCo-operation and Development
OPPTS - Office of Chemical Safety and PollutionPrevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - PhilippinesInventory of Chemicals and Chemical Substances
(Q)SAR - (Quantitative) StructureActivity Relationship
REACH - Regulation (EC) No 1907/2006 of the EuropeanParliament and of the Council concerning the Registration, Evaluation, Authorisation andRestriction of Chemicals
RID - Regulations concerning the International Carriage ofDangerous Goods by Rail
SADT - Self-Accelerating Decomposition Temperature
SDS -Safety Data Sheet
TCSI - Taiwan Chemical Substance Inventory
TECI - ThailandExisting Chemicals Inventory
TSCA - Toxic Substances Control Act (United States)
UN - United Nations
UNRTDG - United Nations Recommendations on the Transport ofDangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
ADR - Agreement concerning the International Carriage ofDangerous Goods by Road
AIIC - Australian Inventory of Industrial Chemicals
ASTM -American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen,Mutagen or Reproductive Toxicant
DIN - Standard of the German Institute forStandardisation
DSL - Domestic Substances List (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS -Emergency Schedule
ENCS - Existing and New Chemical Substances (Japan)
ErCx -Concentration associated with x% growth rate response
GHS - Globally HarmonizedSystem
GLP - Good Laboratory Practice
IARC - International Agency for Research onCancer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 - Half maximal inhibitory concentration
ICAO - International Civil Aviation Organization
IECSC - Inventory of Existing Chemical Substances in China
IMDG - InternationalMaritime Dangerous Goods
IMO - International Maritime Organization
ISHL - IndustrialSafety and Health Law (Japan)
ISO - International Organisation for Standardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concentration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pollution from Ships
n.o.s. -Not Otherwise Specified
NO(A)EC - No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Effect Level
NOELR - No Observable Effect LoadingRate
NZIoC - New Zealand Inventory of Chemicals
OECD - Organization for EconomicCo-operation and Development
OPPTS - Office of Chemical Safety and PollutionPrevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - PhilippinesInventory of Chemicals and Chemical Substances
(Q)SAR - (Quantitative) StructureActivity Relationship
REACH - Regulation (EC) No 1907/2006 of the EuropeanParliament and of the Council concerning the Registration, Evaluation, Authorisation andRestriction of Chemicals
RID - Regulations concerning the International Carriage ofDangerous Goods by Rail
SADT - Self-Accelerating Decomposition Temperature
SDS -Safety Data Sheet
TCSI - Taiwan Chemical Substance Inventory
TECI - ThailandExisting Chemicals Inventory
TSCA - Toxic Substances Control Act (United States)
UN - United Nations
UNRTDG - United Nations Recommendations on the Transport ofDangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.