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ChemicalBook >> CAS DataBase List >> R788(Fostamatinib disodium)

R788(Fostamatinib disodium)

R788(Fostamatinib disodium) price.
  • $44 - $7030
  • Product name: R788(Fostamatinib disodium)
  • CAS: 1025687-58-4
  • MF: C23H27FN6NaO9P
  • MW: 604.46
  • EINECS:-0
  • MDL Number:MFCD15146370
  • Synonyms:R788(Fostamatinib disodium);R788, Fostamatinib;R935788 (FostaMatinib disodiuM);FosD;FOSTAMATINIB;FOSD;TAMATINIB FOSDIUM;Tamatinib Fosdium;R788(prodrug of R406);R935788 (FostaMatinib disodiuM, R788)
26 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1122-M010
  • Product descriptionR788disodiumsalt ≥95%
  • Packaging10mg
  • Price$324
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1122-M050
  • Product descriptionR788disodiumsalt ≥95%
  • Packaging50mg
  • Price$1048
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1122-M100
  • Product descriptionR788disodiumsalt ≥95%
  • Packaging100mg
  • Price$1836
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1122
  • Product descriptionR788disodium
  • Packaging50mg
  • Price$990
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1122
  • Product descriptionR788disodium
  • Packaging100mg
  • Price$1720
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000432
  • Product descriptionFOSTAMATINIB DISODIUM 95.00%
  • Packaging10MG
  • Price$1127.86
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8332
  • Product descriptionR788disodium
  • Packaging10mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8332
  • Product descriptionR788disodium
  • Packaging100mg
  • Price$713
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154619
  • Product descriptionR788 disodium (Fostamatinib) >98%
  • Packaging100mg
  • Price$542.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154619
  • Product descriptionR788 disodium (Fostamatinib) >98%
  • Packaging250mg
  • Price$986
  • Updated2021-12-16
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  • ManufacturerBiorbyt Ltd
  • Product numberorb154619
  • Product descriptionR788 disodium (Fostamatinib) >98%
  • Packaging1g
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18501
  • Product descriptionR788 (sodium salt) ≥95%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18501
  • Product descriptionR788 (sodium salt) ≥95%
  • Packaging5mg
  • Price$193
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number18501
  • Product descriptionR788 (sodium salt) ≥95%
  • Packaging10mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0427
  • Product descriptionFostamatinibDisodium 99.88%
  • Packaging5mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0427
  • Product descriptionFostamatinibDisodium 99.88%
  • Packaging10mg
  • Price$144
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1122-M010 R788disodiumsalt ≥95% 10mg $324 2021-12-16 Buy
Adipogen Life Sciences SYN-1122-M050 R788disodiumsalt ≥95% 50mg $1048 2021-12-16 Buy
Adipogen Life Sciences SYN-1122-M100 R788disodiumsalt ≥95% 100mg $1836 2021-12-16 Buy
AK Scientific SYN1122 R788disodium 50mg $990 2021-12-16 Buy
AK Scientific SYN1122 R788disodium 100mg $1720 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000432 FOSTAMATINIB DISODIUM 95.00% 10MG $1127.86 2021-12-16 Buy
ApexBio Technology A8332 R788disodium 10mg $168 2021-12-16 Buy
ApexBio Technology A8332 R788disodium 100mg $713 2021-12-16 Buy
Biorbyt Ltd orb154619 R788 disodium (Fostamatinib) >98% 100mg $542.3 2021-12-16 Buy
Biorbyt Ltd orb154619 R788 disodium (Fostamatinib) >98% 250mg $986 2021-12-16 Buy
Biorbyt Ltd orb154619 R788 disodium (Fostamatinib) >98% 1g $1949.9 2021-12-16 Buy
Cayman Chemical 18501 R788 (sodium salt) ≥95% 1mg $44 2024-03-01 Buy
Cayman Chemical 18501 R788 (sodium salt) ≥95% 5mg $193 2024-03-01 Buy
Cayman Chemical 18501 R788 (sodium salt) ≥95% 10mg $341 2024-03-01 Buy
ChemScene CS-0427 FostamatinibDisodium 99.88% 5mg $96 2021-12-16 Buy
ChemScene CS-0427 FostamatinibDisodium 99.88% 10mg $144 2021-12-16 Buy

Properties

Melting point :>191°C (dec.)
storage temp. :Store at -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :Off-White
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. R788 is a prodrug of R406 , an inhibitor of Syk (Ki = 30 nM). R788 conversion to the biologically active R406 is catalyzed by the action of alkaline phosphatases present on the apical brush-border of the membranes of intestinal enterocytes. It produces anti-inflammatory and immunomodulating effects by inhibiting Syk-mediated IgG Fcγ receptor signaling, which prevents activation of mast cells, macrophages, and B cells, as well as related inflammatory responses. R788 has undergone clinical evaluation for efficacy in the treatment of rheumatoid arthritis.

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