3PO
|
- $12 - $800
- Product name: 3PO
- CAS: 18550-98-6
- MF: C13H10N2O
- MW: 210.23
- EINECS:
- MDL Number:MFCD00224002
- Synonyms:3PO (inhibitor of glucose metabolism);(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone;3 PO;3-PO;2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-;3PO >=98% (HPLC);inhibitor of glucose metabolism;3PO, 10 mM in DMSO;3PO[SML1343]
36 prices
Selected condition：
Brand
- aablocks
- Acints
- Advanced Chemicals Intermediat
- Arctom
- AvaChem
- Axon Medchem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 25mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 2x50mg
- 10mM*1mLinDMSO
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 10mM(1mLinDMSO)
- Manufactureraablocks
- Product numberAA00AQAP
- Product description(E)-3Po 99%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AQAP
- Product description(E)-3Po 99%
- Packaging5mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AQAP
- Product description(E)-3Po 99%
- Packaging10mg
- Price$19
- Updated2026-05-28
- Buy
- ManufacturerAcints
- Product numberATI-09A-002
- Product description(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable
- Packaging250mg
- Price$67.5
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberATI-09A-002
- Product description(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable
- Packaging1g
- Price$162
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberATI-09A-002
- Product description(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable
- Packaging5g
- Price$486
- Updated2026-05-20
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberATI-09A-002
- Product description(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable
- Packaging250mg
- Price$67.5
- Updated2026-05-19
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberATI-09A-002
- Product description(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable
- Packaging1g
- Price$162
- Updated2026-05-19
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberATI-09A-002
- Product description(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable
- Packaging5g
- Price$486
- Updated2026-05-19
- Buy
- ManufacturerArctom
- Product numberHY-19824
- Product description3PO 99.85%
- Packaging100mg
- Price$415
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7639
- Product description3PO 99.94%
- Packaging25mg
- Price$283
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19824
- Product description3PO 99.85%
- Packaging25mg
- Price$159
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7639
- Product description3PO 99.94%
- Packaging10mM(1mLinDMSO)
- Price$188
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19824
- Product description3PO 99.85%
- Packaging50mg
- Price$239
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19824
- Product description3PO 99.85%
- Packaging10mM*1mLinDMSO(Solution)
- Price$69
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-19824
- Product description3PO 99.85%
- Packaging10mg
- Price$88
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00AQAP | (E)-3Po 99% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA00AQAP | (E)-3Po 99% | 5mg | $16 | 2026-05-28 | Buy |
| aablocks | AA00AQAP | (E)-3Po 99% | 10mg | $19 | 2026-05-28 | Buy |
| Acints | ATI-09A-002 | (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable | 250mg | $67.5 | 2026-05-20 | Buy |
| Acints | ATI-09A-002 | (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable | 1g | $162 | 2026-05-20 | Buy |
| Acints | ATI-09A-002 | (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable | 5g | $486 | 2026-05-20 | Buy |
| Advanced Chemicals Intermediat | ATI-09A-002 | (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable | 250mg | $67.5 | 2026-05-19 | Buy |
| Advanced Chemicals Intermediat | ATI-09A-002 | (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable | 1g | $162 | 2026-05-19 | Buy |
| Advanced Chemicals Intermediat | ATI-09A-002 | (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone Notavailable | 5g | $486 | 2026-05-19 | Buy |
| Arctom | HY-19824 | 3PO 99.85% | 100mg | $415 | 2026-05-26 | Buy |
| Arctom | SLK-S7639 | 3PO 99.94% | 25mg | $283 | 2026-05-26 | Buy |
| Arctom | HY-19824 | 3PO 99.85% | 25mg | $159 | 2026-05-26 | Buy |
| Arctom | SLK-S7639 | 3PO 99.94% | 10mM(1mLinDMSO) | $188 | 2026-05-26 | Buy |
| Arctom | HY-19824 | 3PO 99.85% | 50mg | $239 | 2026-05-26 | Buy |
| Arctom | HY-19824 | 3PO 99.85% | 10mM*1mLinDMSO(Solution) | $69 | 2026-05-26 | Buy |
| Arctom | HY-19824 | 3PO 99.85% | 10mg | $88 | 2026-05-26 | Buy |
Properties
Boiling point :387.8±42.0 °C(Predicted)
Density :1.192±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)
form :powder
pka :3.49±0.11(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+
InChIKey :UOWGYMNWMDNSTL-ONEGZZNKSA-N
SMILES :C(C1C=CN=CC=1)(=O)/C=C/C1=CC=CN=C1
Density :1.192±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)
form :powder
pka :3.49±0.11(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+
InChIKey :UOWGYMNWMDNSTL-ONEGZZNKSA-N
SMILES :C(C1C=CN=CC=1)(=O)/C=C/C1=CC=CN=C1
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
3PO is a competitive inhibitor of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3 (PFKFB3; IC50 = 23 μM) that causes a rapid reduction in fructose 2,6-bisphosphate (F2,6BP), glucose uptake, and lactate secretion. This is followed by a reduction in the steady-state concentration of ATP and NADH, resulting in cell cycle arrest in Jurkat T cell leukemia cells. 3PO is selectively cytostatic to ras-transformed bronchial epithelial cells relative to normal bronchial epithelial cells. 3PO markedly reduces intracellular F2,6BP, glucose uptake, and growth of established tumors in mice. It also blocks angiogenesis, reducing vessel sprouting in endothelial cell spheroids, zebrafish embryos, and the postnatal mouse retina by inhibiting endothelial cell proliferation and migration.Related product price
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Shenzhen Shengda Pharma Limited
BOC Sciences
Nanjing Doge Biomedical Technology Co., Ltd
Nantong HI-FUTURE Biology Co., Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
HANGZHOU LEAP CHEM CO., LTD.
Shanghai Acmec Biochemical Technology Co., Ltd.
Jilin Chinese Academy of Sciences-yanshen Technology
