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ChemicalBook >> CAS DataBase List >> CPI-455

CPI-455

CPI-455 price.
  • $9 - $2008
  • Product name: CPI-455
  • CAS: 1628208-23-0
  • MF: C16H14N4O
  • MW: 278.31
  • EINECS:-0
  • MDL Number:MFCD29921343
  • Synonyms:CPI 455;CPI455;CPI 455;CPI-455;CPI455;CPI-455, >98%;CPI-455(free base);CPI-455;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-;CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit
Price47 Properties Safety Information Description
47 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • AvaChem
  • Axon Medchem
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Synthonix
Package
  • 10mM*1mLinDMSO
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 2x25mg
  • 50mg
  • 100.00mg
  • 100mg
  • 0.1g
  • 250.00mg
  • 250mg
  • 0.25g
  • 0.5g
  • 1g
  • 1.00g
  • 2g
  • 5g
  • 10g
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98%
  • Packaging1mg
  • Price$9
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile ≥98%
  • Packaging5mg
  • Price$11
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98%
  • Packaging10mg
  • Price$20
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile ≥98%
  • Packaging25mg
  • Price$25
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98%
  • Packaging100mg
  • Price$56
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98%
  • Packaging250mg
  • Price$107
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95%
  • Packaging1g
  • Price$396
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95%
  • Packaging5g
  • Price$1342
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95%
  • Packaging10g
  • Price$2008
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33798
  • Product descriptionCPI-455 98%
  • Packaging1G
  • Price$395
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33798
  • Product descriptionCPI-455 98%
  • Packaging100MG
  • Price$70
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberO33798
  • Product descriptionCPI-455 98%
  • Packaging25MG
  • Price$30
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number1814DY
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
  • Packaging5mg
  • Price$289
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7811
  • Product description6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
  • Packaging25mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7811
  • Product description6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number6230
  • Product descriptionCPI-455 98%
  • Packaging5mg
  • Price$90
  • Updated2026-05-22
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98% 1mg $9 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile ≥98% 5mg $11 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98% 10mg $20 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile ≥98% 25mg $25 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98% 100mg $56 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98% 250mg $107 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95% 1g $396 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95% 5g $1342 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95% 10g $2008 2026-05-28 Buy
ACHEMBLOCK O33798 CPI-455 98% 1G $395 2026-05-27 Buy
ACHEMBLOCK O33798 CPI-455 98% 100MG $70 2026-05-27 Buy
ACHEMBLOCK O33798 CPI-455 98% 25MG $30 2026-05-27 Buy
AK Scientific 1814DY 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 5mg $289 2021-12-16 Buy
ApexBio Technology B7811 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride 25mg $320 2021-12-16 Buy
ApexBio Technology B7811 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride 5mg $85 2021-12-16 Buy
AvaChem 6230 CPI-455 98% 5mg $90 2026-05-22 Buy
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Properties

Boiling point :488.7±55.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :-5.10±0.60(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.

Description

CPI-455 (1628208-23-0) is a potent (IC50= 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2’-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cellsin vitro.2KDM5 demethylases have recently been shown to repress the immune response to tumorsviasuppression of STING.3

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Suppliers and manufacturers

career henan chemical co
CPI-455
$1.00
CPI-455 CAS:1628208-23-0
TargetMol Chemicals Inc.
CPI-455
$31.00
CPI-455 CAS:1628208-23-0
BOC Sciences
TargetMol Chemicals Inc.
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
NANJING YINGWEN BIOTECHNOLOGY CO LTD
Amadis Chemical Company Limited Shanghai Lollane Biological Technology Co.,Ltd. Shanghai EFE Biological Technology Co., Ltd.