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ChemicalBook >> CAS DataBase List >> GNE 7915

GNE 7915

$24 - $2541.5
Product name: GNE 7915
CAS: 1351761-44-8
MF: C19H21F4N5O3
MW: 443.4
EINECS:
MDL Number:MFCD25977005
Synonyms:GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;CS-1279;GNE7915; GNE 7915;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-

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Brand

aablocks
ACHEMBLOCK
Acrotein
Activate Scientific
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Axon Medchem
Biorbyt Ltd
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Synthonix
TRC
Usbiological

Package

10mM*1mLinDMSO
1mg
10mM(in1mLDMSO)
5mg
10.00mg
10mg
25mg
50.00mg
50mg
10mM(in 1mL DMSO)
100mg
100.00mg
200mg
250mg
0.25g
1g
1000mg

Manufactureraablocks
Product numberAA009C92
Product description[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 99%
Packaging1mg
Price$24
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009C92
Product description[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 99%
Packaging5mg
Price$29
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009C92
Product description[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 99%
Packaging10mg
Price$42
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009C92
Product description[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 99%
Packaging50mg
Price$50
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009C92
Product description[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 95%
Packaging100mg
Price$90
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009C92
Product description[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 95%
Packaging250mg
Price$207
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009C92
Product description[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 95%
Packaging1g
Price$613
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberT101912
Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
Packaging1G
Price$935
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberT101912
Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
Packaging1G
Price$935
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberT101912
Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
Packaging250MG
Price$245
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberT101912
Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
Packaging250MG
Price$245
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberT101912
Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
Packaging100MG
Price$105
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberT101912
Product description(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%
Packaging100MG
Price$105
Updated2026-05-27
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ManufacturerAcrotein
Product numberdm-2712
Product descriptionGNE7915 97%
Packaging100mg
Price$385
Updated2026-05-25
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ManufacturerAcrotein
Product numberdm-2712
Product descriptionGNE7915 97%
Packaging25mg
Price$165
Updated2026-05-25
Buy

ManufacturerAcrotein
Product numberdm-2712
Product descriptionGNE7915 97%
Packaging0.25g
Price$788.34
Updated2026-05-25
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA009C92	[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 99%	1mg	$24	2026-05-28	Buy
aablocks	AA009C92	[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 99%	5mg	$29	2026-05-28	Buy
aablocks	AA009C92	[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 99%	10mg	$42	2026-05-28	Buy
aablocks	AA009C92	[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 99%	50mg	$50	2026-05-28	Buy
aablocks	AA009C92	[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 95%	100mg	$90	2026-05-28	Buy
aablocks	AA009C92	[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 95%	250mg	$207	2026-05-28	Buy
aablocks	AA009C92	[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone 95%	1g	$613	2026-05-28	Buy
ACHEMBLOCK	T101912	(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%	1G	$935	2026-05-25	Buy
ACHEMBLOCK	T101912	(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%	1G	$935	2026-05-27	Buy
ACHEMBLOCK	T101912	(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%	250MG	$245	2026-05-25	Buy
ACHEMBLOCK	T101912	(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%	250MG	$245	2026-05-27	Buy
ACHEMBLOCK	T101912	(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%	100MG	$105	2026-05-25	Buy
ACHEMBLOCK	T101912	(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone 98%	100MG	$105	2026-05-27	Buy
Acrotein	dm-2712	GNE7915 97%	100mg	$385	2026-05-25	Buy
Acrotein	dm-2712	GNE7915 97%	25mg	$165	2026-05-25	Buy
Acrotein	dm-2712	GNE7915 97%	0.25g	$788.34	2026-05-25	Buy

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Properties

Melting point :143 - 144°C
Boiling point :629.9±65.0 °C(Predicted)
Density :1.404±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Chloroform (Slightly), DMSO (Slightly)
form :solid
pka :2.80±0.10(Predicted)
color :Off-white to light yellow
InChI :InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
InChIKey :XCFLWTZSJYBCPF-UHFFFAOYSA-N
SMILES :C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)(N1CCOCC1)=O
CAS DataBase Reference :1351761-44-8

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.

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Suppliers and manufacturers

career henan chemical co

$1.00
GNE 7915 CAS:1351761-44-8

TargetMol Chemicals Inc.

$56.00
GNE-7915 CAS:1351761-44-8

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GNE 7915

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