GNE 7915
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- $60 - $2541.5
- Product name: GNE 7915
- CAS: 1351761-44-8
- MF: C19H21F4N5O3
- MW: 443.4
- EINECS:
- MDL Number:MFCD25977005
- Synonyms:GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;CS-1279;GNE7915; GNE 7915;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
22 prices
Selected condition：
Brand
- Acrotein
- Activate Scientific
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1000mg
- 10mM(in 1mL DMSO)
- ManufacturerAcrotein
- Product numberDM-2712
- Product descriptionGNE7915 97%
- Packaging100mg
- Price$385
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS106813
- Product descriptionGNE7915 97%
- Packaging100mg
- Price$515
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5761
- Product descriptionGNE-7915
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004720
- Product description[4-[[4-(ETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIMIDINYL]AMINO]-2-FLUORO-5-METHOXYPHENYL]-4-MORPHOLINYL-METHANONE 95.00%
- Packaging5MG
- Price$497.78
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3605
- Product descriptionGNE-7915
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3605
- Product descriptionGNE-7915
- Packaging10mM(in 1mL DMSO)
- Price$112
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3605
- Product descriptionGNE-7915
- Packaging25mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3605
- Product descriptionGNE-7915
- Packaging100mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2348
- Product descriptionGNE7915 99%
- Packaging50mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181249
- Product descriptionGNE-7915 >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181249
- Product descriptionGNE-7915 >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181249
- Product descriptionGNE-7915 >98%
- Packaging1000mg
- Price$2541.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16252
- Product descriptionGNE-7915 ≥98%
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16252
- Product descriptionGNE-7915 ≥98%
- Packaging10mg
- Price$166
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16252
- Product descriptionGNE-7915 ≥98%
- Packaging50mg
- Price$547
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31003778
- Product descriptionGNE-7915 98+%
- Packaging50mg
- Price$359
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Acrotein | DM-2712 | GNE7915 97% | 100mg | $385 | 2021-12-16 | Buy |
| Activate Scientific | AS106813 | GNE7915 97% | 100mg | $515 | 2021-12-16 | Buy |
| AK Scientific | SYN5761 | GNE-7915 | 10mg | $160 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004720 | [4-[[4-(ETHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIMIDINYL]AMINO]-2-FLUORO-5-METHOXYPHENYL]-4-MORPHOLINYL-METHANONE 95.00% | 5MG | $497.78 | 2021-12-16 | Buy |
| ApexBio Technology | B3605 | GNE-7915 | 5mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | B3605 | GNE-7915 | 10mM(in 1mL DMSO) | $112 | 2021-12-16 | Buy |
| ApexBio Technology | B3605 | GNE-7915 | 25mg | $200 | 2021-12-16 | Buy |
| ApexBio Technology | B3605 | GNE-7915 | 100mg | $470 | 2021-12-16 | Buy |
| Axon Medchem | Axon2348 | GNE7915 99% | 50mg | $396 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181249 | GNE-7915 >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181249 | GNE-7915 >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181249 | GNE-7915 >98% | 1000mg | $2541.5 | 2021-12-16 | Buy |
| Cayman Chemical | 16252 | GNE-7915 ≥98% | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 16252 | GNE-7915 ≥98% | 10mg | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 16252 | GNE-7915 ≥98% | 50mg | $547 | 2024-03-01 | Buy |
| Crysdot | CD31003778 | GNE-7915 98+% | 50mg | $359 | 2021-12-16 | Buy |
Properties
Melting point :143 - 144°C
Boiling point :629.9±65.0 °C(Predicted)
Density :1.404±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Chloroform (Slightly), DMSO (Slightly)
form :solid
pka :2.80±0.10(Predicted)
color :Off-white to light yellow
InChI :InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
InChIKey :XCFLWTZSJYBCPF-UHFFFAOYSA-N
SMILES :C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)(N1CCOCC1)=O
CAS DataBase Reference :1351761-44-8
Boiling point :629.9±65.0 °C(Predicted)
Density :1.404±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Chloroform (Slightly), DMSO (Slightly)
form :solid
pka :2.80±0.10(Predicted)
color :Off-white to light yellow
InChI :InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
InChIKey :XCFLWTZSJYBCPF-UHFFFAOYSA-N
SMILES :C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)(N1CCOCC1)=O
CAS DataBase Reference :1351761-44-8
Safety Information
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Description
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.Related product price
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