IPI-549
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- $24 - $3450
- Product name: IPI-549
- CAS: 1693758-51-8
- MF: C30H24N8O2
- MW: 528.56
- EINECS:-0
- MDL Number:MFCD30533720
- Synonyms:IPI-549;(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;IPI-549(IPI549);IPI-549, 98%, a potent and selective PI3Kγ Inhibitor;CS-2414;IPI-549; IPI 549; IPI549.;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-;IPI549 (Eganelisib)
46 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Activate Scientific
- American Custom Chemicals Corporation
- Apolloscientific
- AvaChem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 2mg
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1G
- 5G
- Manufactureraablocks
- Product numberAA00ASAK
- Product descriptionIPI-549 98%
- Packaging1mg
- Price$24
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ASAK
- Product descriptionIPI-549 98%
- Packaging5mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ASAK
- Product descriptionIPI-549 98%
- Packaging10mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ASAK
- Product descriptionIPI-549 98%
- Packaging25mg
- Price$81
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ASAK
- Product descriptionIPI-549 98%
- Packaging50mg
- Price$140
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ASAK
- Product descriptionIPI-549 98%
- Packaging100mg
- Price$256
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65457
- Product description(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98%
- Packaging100MG
- Price$320
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65457
- Product description(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98%
- Packaging25MG
- Price$100
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65457
- Product description(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98%
- Packaging5MG
- Price$35
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65457
- Product description(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98%
- Packaging1G
- Price$1250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65457
- Product description(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98%
- Packaging5G
- Price$3450
- Updated2026-05-27
- Buy
- ManufacturerActivate Scientific
- Product numberAS118143
- Product descriptionIPI-549 98+%
- Packaging100mg
- Price$1141
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS118143
- Product descriptionIPI-549 98+%
- Packaging1mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPRK0000449
- Product description(S)-2-AMINO-N-(1-(8-((1-METHYL-1H-PYRAZOL-4-YL)ETHYNYL)-1-OXO-2-PHENYL-1,2-DIHYDROISOQUINOLIN-3-YL)ETHYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE 95.00%
- Packaging5MG
- Price$458.64
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0153
- Product descriptionIPI-549 98%
- Packaging100mg
- Price$396
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBISN0153
- Product descriptionIPI-549 98%
- Packaging50mg
- Price$217
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ASAK | IPI-549 98% | 1mg | $24 | 2026-05-28 | Buy |
| aablocks | AA00ASAK | IPI-549 98% | 5mg | $29 | 2026-05-28 | Buy |
| aablocks | AA00ASAK | IPI-549 98% | 10mg | $46 | 2026-05-28 | Buy |
| aablocks | AA00ASAK | IPI-549 98% | 25mg | $81 | 2026-05-28 | Buy |
| aablocks | AA00ASAK | IPI-549 98% | 50mg | $140 | 2026-05-28 | Buy |
| aablocks | AA00ASAK | IPI-549 98% | 100mg | $256 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q65457 | (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98% | 100MG | $320 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65457 | (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98% | 25MG | $100 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65457 | (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98% | 5MG | $35 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65457 | (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98% | 1G | $1250 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65457 | (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98% | 5G | $3450 | 2026-05-27 | Buy |
| Activate Scientific | AS118143 | IPI-549 98+% | 100mg | $1141 | 2021-12-16 | Buy |
| Activate Scientific | AS118143 | IPI-549 98+% | 1mg | $79 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PRK0000449 | (S)-2-AMINO-N-(1-(8-((1-METHYL-1H-PYRAZOL-4-YL)ETHYNYL)-1-OXO-2-PHENYL-1,2-DIHYDROISOQUINOLIN-3-YL)ETHYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE 95.00% | 5MG | $458.64 | 2021-12-16 | Buy |
| Apolloscientific | BISN0153 | IPI-549 98% | 100mg | $396 | 2026-06-04 | Buy |
| Apolloscientific | BISN0153 | IPI-549 98% | 50mg | $217 | 2026-06-04 | Buy |
Properties
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :10.81±0.46(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :XUMALORDVCFWKV-IBGZPJMESA-N
SMILES :C12=C(C(N[C@H](C3=CC4=C(C(=O)N3C3=CC=CC=C3)C(C#CC3=CN(C)N=C3)=CC=C4)C)=O)C(N)=NN1C=CC=N2
CAS DataBase Reference :1693758-51-8
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :10.81±0.46(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :XUMALORDVCFWKV-IBGZPJMESA-N
SMILES :C12=C(C(N[C@H](C3=CC4=C(C(=O)N3C3=CC=CC=C3)C(C#CC3=CN(C)N=C3)=CC=C4)C)=O)C(N)=NN1C=CC=N2
CAS DataBase Reference :1693758-51-8
Safety Information
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Description
IPI-549 (1693758-51-8) is a potent and highly selective inhibitor of PI3K-γ in both biochemical (IC50= 16 nM) and cellular (IC50= 12.2 nM) assays.1Macrophage PI3K-γ has been found to be a critical switch between immune stimulation and suppression.2IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3K-γ inhibition via IPI-549.3IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines.3IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance.4More related product prices
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Suppliers and manufacturers
Shanghai YuanQi Biotechnology Co., Ltd.
Twochem Co.Ltd.
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Chembest Research Laboratories Limited
Nanjing Chemlin Chemical Co., Ltd
Shanghai Topbiochem Technology Co., Ltd
Shanghai Jian Chao Chemical Technology Co., Ltd.
ShangHai Caerulum Pharma Discovery Co., Ltd.
DKMbiochem.Co. Ltd
Finetech Industry Limited