K 02288
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- $37 - $2841
- Product name: K 02288
- CAS: 1431985-92-0
- MF: C20H20N2O4
- MW: 352.38
- EINECS:
- MDL Number:MFCD26936347
- Synonyms:LM-3151 K02288;K 02288;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-;K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K 02288(K 02288a);K02288;K 02288;K-02288;CS-1877
51 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 100mg
- 1g
- 10mM*1mLinDMSO(Solution)
- 10
- 50
- 10mM*1mLinDMSO
- 250mg
- 10mg
- 10mM(in 1mL DMSO)
- 5mg
- 50mg
- 25mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(in1mLDMSO)
- 10mM(1mLinDMSO)
- ManufacturerAK Scientific
- Product numberY1876
- Product descriptionK02288
- Packaging10mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY1876
- Product descriptionK02288
- Packaging50mg
- Price$771
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151373
- Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151373
- Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151373
- Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
- Packaging50mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2286
- Product descriptionK02288
- Packaging10mM(in 1mL DMSO)
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2286
- Product descriptionK02288
- Packaging10mg
- Price$149
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB2286
- Product descriptionK02288
- Packaging10mM(in1mLDMSO)
- Price$154
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB2286
- Product descriptionK02288
- Packaging50mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2286
- Product descriptionK02288
- Packaging50mg
- Price$475
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-12278
- Product descriptionK02288 99.65%
- Packaging50mg
- Price$333
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7359
- Product descriptionK02288 99.84%
- Packaging10mM(1mLinDMSO)
- Price$257
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7359
- Product descriptionK02288 99.84%
- Packaging10mg
- Price$188
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12278
- Product descriptionK02288 99.65%
- Packaging25mg
- Price$209
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12278
- Product descriptionK02288 99.65%
- Packaging10mg
- Price$105
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12278
- Product descriptionK02288 99.65%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$65
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y1876 | K02288 | 10mg | $243 | 2021-12-16 | Buy |
| AK Scientific | Y1876 | K02288 | 50mg | $771 | 2021-12-16 | Buy |
| Ambeed | A151373 | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% | 5mg | $50 | 2021-12-16 | Buy |
| Ambeed | A151373 | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% | 10mg | $65 | 2021-12-16 | Buy |
| Ambeed | A151373 | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% | 50mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B2286 | K02288 | 10mM(in 1mL DMSO) | $149 | 2021-12-16 | Buy |
| ApexBio Technology | B2286 | K02288 | 10mg | $149 | 2026-05-06 | Buy |
| ApexBio Technology | B2286 | K02288 | 10mM(in1mLDMSO) | $154 | 2026-05-06 | Buy |
| ApexBio Technology | B2286 | K02288 | 50mg | $450 | 2021-12-16 | Buy |
| ApexBio Technology | B2286 | K02288 | 50mg | $475 | 2026-05-06 | Buy |
| Arctom | HY-12278 | K02288 99.65% | 50mg | $333 | 2026-05-26 | Buy |
| Arctom | SLK-S7359 | K02288 99.84% | 10mM(1mLinDMSO) | $257 | 2026-05-26 | Buy |
| Arctom | SLK-S7359 | K02288 99.84% | 10mg | $188 | 2026-05-26 | Buy |
| Arctom | HY-12278 | K02288 99.65% | 25mg | $209 | 2026-05-26 | Buy |
| Arctom | HY-12278 | K02288 99.65% | 10mg | $105 | 2026-05-26 | Buy |
| Arctom | HY-12278 | K02288 99.65% | 10mM*1mLinDMSO(Solid+Solvent) | $65 | 2026-05-26 | Buy |
Properties
Melting point :201-203°C
Boiling point :522.2±50.0 °C(Predicted)
Density :1.232±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :powder
pka :9.33±0.10(Predicted)
color :white to beige
InChI :1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
InChIKey :CJLMANFTWLNAKC-UHFFFAOYSA-N
SMILES :NC1=C(C2=CC(OC)=C(OC)C(OC)=C2)C=C(C3=CC=CC(O)=C3)C=N1
Boiling point :522.2±50.0 °C(Predicted)
Density :1.232±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :powder
pka :9.33±0.10(Predicted)
color :white to beige
InChI :1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
InChIKey :CJLMANFTWLNAKC-UHFFFAOYSA-N
SMILES :NC1=C(C2=CC(OC)=C(OC)C(OC)=C2)C=C(C3=CC=CC(O)=C3)C=N1
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
| Hazard statements: |
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Description
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.More related product prices
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