PP242
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- $28 - $8326
- Product name: PP242
- CAS: 1092351-67-1
- MF: C16H16N6O
- MW: 308.34
- EINECS:-0
- MDL Number:MFCD12196869
- Synonyms:PP242;2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol;PP242, Free Base;Torkinib;PP242 (Torkinib);TORKINIB;PP242; PP-242;PP 242;CS-19;(2E)-2-(4-amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol
48 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
- Tocris
- TRC
- Usbiological
Package
- 1unit
- 5
- 25
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 1000mg
- 5g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1181-M001
- Product descriptionPP242 ≥95%
- Packaging1mg
- Price$54
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1181-M050
- Product descriptionPP242 ≥95%
- Packaging50mg
- Price$394
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1181
- Product descriptionPP242
- Packaging10mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1181
- Product descriptionPP242
- Packaging100mg
- Price$625
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228542
- Product descriptionPP242 98+%
- Packaging5mg
- Price$34
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228542
- Product descriptionPP242 98+%
- Packaging10mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228542
- Product descriptionPP242 98+%
- Packaging50mg
- Price$74
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228542
- Product descriptionPP242 98+%
- Packaging100mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228542
- Product descriptionPP242 98+%
- Packaging250mg
- Price$231
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA228542
- Product descriptionPP242 98+%
- Packaging1g
- Price$572
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8318
- Product descriptionPP242
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8318
- Product descriptionPP242
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8318
- Product descriptionPP242
- Packaging25mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0004
- Product descriptionPP242
- Packaging5mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0004
- Product descriptionPP242
- Packaging10mg
- Price$102
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIFK0004
- Product descriptionPP242
- Packaging50mg
- Price$189
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1181-M001 | PP242 ≥95% | 1mg | $54 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1181-M050 | PP242 ≥95% | 50mg | $394 | 2021-12-16 | Buy |
| AK Scientific | SYN1181 | PP242 | 10mg | $130 | 2021-12-16 | Buy |
| AK Scientific | SYN1181 | PP242 | 100mg | $625 | 2021-12-16 | Buy |
| Ambeed | A228542 | PP242 98+% | 5mg | $34 | 2021-12-16 | Buy |
| Ambeed | A228542 | PP242 98+% | 10mg | $44 | 2021-12-16 | Buy |
| Ambeed | A228542 | PP242 98+% | 50mg | $74 | 2021-12-16 | Buy |
| Ambeed | A228542 | PP242 98+% | 100mg | $118 | 2021-12-16 | Buy |
| Ambeed | A228542 | PP242 98+% | 250mg | $231 | 2021-12-16 | Buy |
| Ambeed | A228542 | PP242 98+% | 1g | $572 | 2021-12-16 | Buy |
| ApexBio Technology | A8318 | PP242 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A8318 | PP242 | 5mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A8318 | PP242 | 25mg | $150 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0004 | PP242 | 5mg | $68 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0004 | PP242 | 10mg | $102 | 2021-12-16 | Buy |
| Apolloscientific | BIFK0004 | PP242 | 50mg | $189 | 2021-12-16 | Buy |
Properties
Melting point :>187°C (dec.)
Boiling point :642.0±50.0 °C(Predicted)
Density :1.55
Flash point :342.097℃
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly, Sonicated)
form :White powder solid.
pka :9.51±0.40(Predicted)
color :Pale Brown to Light Brown
Boiling point :642.0±50.0 °C(Predicted)
Density :1.55
Flash point :342.097℃
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly, Sonicated)
form :White powder solid.
pka :9.51±0.40(Predicted)
color :Pale Brown to Light Brown
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||
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Description
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin) and regulate different pathways. PP242 is an inhibitor of the active site of mTOR kinase in both mTORC1 and mTORC2 (IC50 = 8 nM). It less effectively inhibits PKCα, PI3-kinase subunit p110γ, JAK2, PKCβI, and PKCβII (IC50 = 49, 102, 110, 198, and 185, respectively). PP242 has been shown to cause the death of certain human and murine leukemia cells more potently than rapamycin and, in vivo, delays leukemia onset and augments the effects of tyrosine kinase inhibitors in suppressing leukemic expansion and extending survival.More related product prices
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