Repotrectinib
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- $8 - $1600
- Product name: Repotrectinib
- CAS: 1802220-02-5
- MF: C18H18FN5O2
- MW: 355.37
- EINECS:125-417-3
- MDL Number:MFCD31544350
- Synonyms:Ropotrectinib;TPX-0005;TPX 0005;TPX0005;CS-2479;Repotrectinib(TPX-005);Repotrectinib;Repotrectinib,TPX-0005;1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-;TPX-0005,Repotrectinib
44 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
Package
- 2mg
- 250.00mg
- 1g
- 10mM*1mLinDMSO
- 50mg
- 1.00g
- 5.00g
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 250mg
- 25mg
- 100mg
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging1mg
- Price$8
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging5mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- ≥98%
- Packaging10mg
- Price$17
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging25mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging100mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003ARB
- Product description1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99%
- Packaging250mg
- Price$61
- Updated2026-05-28
- Buy
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging5mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging10mg
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging25mg
- Price$691
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4650
- Product descriptionRepotrectinib
- Packaging25mg
- Price$307
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4650
- Product descriptionRepotrectinib
- Packaging5mg
- Price$100
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4650
- Product descriptionRepotrectinib
- Packaging10mg
- Price$150
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-103022
- Product descriptionRepotrectinib 99.95%
- Packaging10mg
- Price$168
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-103022
- Product descriptionRepotrectinib 99.95%
- Packaging5mg
- Price$105
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-103022
- Product descriptionRepotrectinib 99.95%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$115
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-103022
- Product descriptionRepotrectinib 99.95%
- Packaging10mM*1mLinDMSO(Solution)
- Price$115
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 1mg | $8 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 5mg | $11 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- ≥98% | 10mg | $17 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 25mg | $19 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 100mg | $38 | 2026-05-28 | Buy |
| aablocks | AA003ARB | 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- 99% | 250mg | $61 | 2026-05-28 | Buy |
| AK Scientific | 3224EM | Repotrectinib | 5mg | $252 | 2021-12-16 | Buy |
| AK Scientific | 3224EM | Repotrectinib | 10mg | $370 | 2021-12-16 | Buy |
| AK Scientific | 3224EM | Repotrectinib | 25mg | $691 | 2021-12-16 | Buy |
| ApexBio Technology | A4650 | Repotrectinib | 25mg | $307 | 2026-05-06 | Buy |
| ApexBio Technology | A4650 | Repotrectinib | 5mg | $100 | 2026-05-06 | Buy |
| ApexBio Technology | A4650 | Repotrectinib | 10mg | $150 | 2026-05-06 | Buy |
| Arctom | HY-103022 | Repotrectinib 99.95% | 10mg | $168 | 2026-05-26 | Buy |
| Arctom | HY-103022 | Repotrectinib 99.95% | 5mg | $105 | 2026-05-26 | Buy |
| Arctom | HY-103022 | Repotrectinib 99.95% | 10mM*1mLinDMSO(Solid+Solvent) | $115 | 2026-05-26 | Buy |
| Arctom | HY-103022 | Repotrectinib 99.95% | 10mM*1mLinDMSO(Solution) | $115 | 2026-05-26 | Buy |
Properties
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM) form :A crystalline solid
pka :10.79±0.60(Predicted)
color :White to off-white
InChI :InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
InChIKey :FIKPXCOQUIZNHB-WDEREUQCSA-N
SMILES :O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C
storage temp. :Store at -20°C
solubility :DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM) form :A crystalline solid
pka :10.79±0.60(Predicted)
color :White to off-white
InChI :InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
InChIKey :FIKPXCOQUIZNHB-WDEREUQCSA-N
SMILES :O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Ropotrectinib (TPX-0005; TP Therapeutics, San Diego, CA, USA) is a nextgeneration ROS1 inhibitor, a novel three-dimensional macrocyle with a much smaller size (MW <370) than current ROS1 inhibitors. It was specifically designed to overcome resistance mutations. Preclinical studies have shown activity against gatekeeper and solvent mutations, including G2032R, D2033N, L2026M, S1986F/Y, L1951R, and kinases involved in bypass signaling such as focal adhesion kinase, SRC proto-oncogene, and non-receptor tyrosine kinase [102, 103].Related product price
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Anqing Benro pharmachem Technology Co.,Ltd.
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