TM 5275
|
- $31 - $4370
- Product name: TM 5275
- CAS: 1103926-82-4
- MF: C28H29ClN3NaO5
- MW: 546
- EINECS:
- MDL Number:MFCD28396414
- Synonyms:TM 5275;TM 5275 sodium salt;TM5275 (sodium);CS-2524;TM 5275;TM-5275;2-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-5-chlorobenzoic acid sodium salt;5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt;TM5275 sodium salt >=98% (HPLC)
60 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10mM*1mLinDMSO
- 1mg
- 2mg
- 50
- 5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mg
- 25mg
- 50mg
- 100mg
- 10
- 250MG
- 1G
- 5G
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA0097DG
- Product descriptionTM5275 sodium 98%
- Packaging1mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0097DG
- Product descriptionTM5275 sodium 98
- Packaging2mg
- Price$48
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0097DG
- Product descriptionTM5275 sodium 98%
- Packaging5mg
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0097DG
- Product descriptionTM5275 sodium 98%
- Packaging10mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0097DG
- Product descriptionTM5275 sodium 98%
- Packaging25mg
- Price$112
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0097DG
- Product descriptionTM5275 sodium 98%
- Packaging50mg
- Price$145
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0097DG
- Product descriptionTM5275 sodium 98%
- Packaging100mg
- Price$245
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203343
- Product descriptionTM5275 sodium salt 98.00%
- Packaging250MG
- Price$560
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203343
- Product descriptionTM5275 sodium salt 98.00%
- Packaging1G
- Price$1680
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203343
- Product descriptionTM5275 sodium salt 98.00%
- Packaging5G
- Price$4370
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number4321DK
- Product descriptionSodium;2-[[2-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-5-chlorobenzoate
- Packaging5mg
- Price$226
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA873934
- Product descriptionTM5275 98%
- Packaging5mg
- Price$202
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA873934
- Product descriptionTM5275 98%
- Packaging10mg
- Price$262
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA873934
- Product descriptionTM5275 98%
- Packaging25mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA873934
- Product descriptionTM5275 98%
- Packaging2mg
- Price$107
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA873934
- Product descriptionTM5275 98%
- Packaging1mg
- Price$67
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0097DG | TM5275 sodium 98% | 1mg | $31 | 2026-05-28 | Buy |
| aablocks | AA0097DG | TM5275 sodium 98 | 2mg | $48 | 2026-05-28 | Buy |
| aablocks | AA0097DG | TM5275 sodium 98% | 5mg | $68 | 2026-05-28 | Buy |
| aablocks | AA0097DG | TM5275 sodium 98% | 10mg | $87 | 2026-05-28 | Buy |
| aablocks | AA0097DG | TM5275 sodium 98% | 25mg | $112 | 2026-05-28 | Buy |
| aablocks | AA0097DG | TM5275 sodium 98% | 50mg | $145 | 2026-05-28 | Buy |
| aablocks | AA0097DG | TM5275 sodium 98% | 100mg | $245 | 2026-05-28 | Buy |
| ACHEMBLOCK | X203343 | TM5275 sodium salt 98.00% | 250MG | $560 | 2026-05-27 | Buy |
| ACHEMBLOCK | X203343 | TM5275 sodium salt 98.00% | 1G | $1680 | 2026-05-27 | Buy |
| ACHEMBLOCK | X203343 | TM5275 sodium salt 98.00% | 5G | $4370 | 2026-05-27 | Buy |
| AK Scientific | 4321DK | Sodium;2-[[2-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-5-chlorobenzoate | 5mg | $226 | 2021-12-16 | Buy |
| Ambeed | A873934 | TM5275 98% | 5mg | $202 | 2021-12-16 | Buy |
| Ambeed | A873934 | TM5275 98% | 10mg | $262 | 2021-12-16 | Buy |
| Ambeed | A873934 | TM5275 98% | 25mg | $340 | 2021-12-16 | Buy |
| Ambeed | A873934 | TM5275 98% | 2mg | $107 | 2021-12-16 | Buy |
| Ambeed | A873934 | TM5275 98% | 1mg | $67 | 2021-12-16 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO:20.0(Max Conc. mg/mL);36.77(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.11(Max Conc. mg/mL);0.2(Max Conc. mM)
DMF:33.0(Max Conc. mg/mL);60.66(Max Conc. mM) form :powder
color :white to beige
InChIKey :JSHSGBIWNPQCQZ-UHFFFAOYSA-M
SMILES :O=C(COCC(NC1=C(C([O-])=O)C=C(Cl)C=C1)=O)N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2.[Na+]
solubility :DMSO:20.0(Max Conc. mg/mL);36.77(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.11(Max Conc. mg/mL);0.2(Max Conc. mM)
DMF:33.0(Max Conc. mg/mL);60.66(Max Conc. mM) form :powder
color :white to beige
InChIKey :JSHSGBIWNPQCQZ-UHFFFAOYSA-M
SMILES :O=C(COCC(NC1=C(C([O-])=O)C=C(Cl)C=C1)=O)N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2.[Na+]
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | |||||||||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 6.95 μM), a serine-protease inhibitor involved in thrombosis. TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs) in vitro, prolonging the time that tPA is retained on VECs. It also enhances fibrin clot dissolution and plasminogen accumulation in vitro and has antithrombotic effects in rat models of thrombosis. TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.Related product price
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