VTX-2337
|
- $28 - $4062
- Product name: VTX-2337
- CAS: 926927-61-9
- MF: C28H34N4O2
- MW: 458.6
- EINECS:
- MDL Number:MFCD28044318
- Synonyms:2-amino-n,n-dipropyl-8-[4-(pyrrolidine-1-carbonyl)phenyl]-3h-1-benzazepine-4-carboxamide;VTX-2337;VTX 378;2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide;Motolimod(VTX-2337);VTX 2337;VTX2337;VTX-378;VTX 2337;VTX2337;CS-1536
50 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
Package
- 10mM*1mLinDMSO
- 1mg
- 2mg
- 1mlx10mM(inDMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 10mM(in1mLDMSO)
- 100MG
- 250mg
- 500mg
- 1G
- Manufactureraablocks
- Product numberAA003A5O
- Product description2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99%
- Packaging1mg
- Price$28
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A5O
- Product description2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99%
- Packaging2mg
- Price$45
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A5O
- Product description2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99%
- Packaging5mg
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A5O
- Product description2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99%
- Packaging10mg
- Price$99
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A5O
- Product description2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99%
- Packaging25mg
- Price$168
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A5O
- Product description2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99%
- Packaging50mg
- Price$267
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13490
- Product descriptionVTX-2337 98%
- Packaging100MG
- Price$405
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13490
- Product descriptionVTX-2337 98%
- Packaging25MG
- Price$171
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13490
- Product descriptionVTX-2337 98%
- Packaging5MG
- Price$68
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13490
- Product descriptionVTX-2337 98%
- Packaging1G
- Price$1755
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2129CW
- Product descriptionMotolimod
- Packaging1mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5996
- Product descriptionMotolimod (VTX-2337)
- Packaging5mg
- Price$143
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5996
- Product descriptionMotolimod (VTX-2337)
- Packaging10mM(in1mLDMSO)
- Price$149
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5996
- Product descriptionMotolimod (VTX-2337)
- Packaging25mg
- Price$418
- Updated2026-05-06
- Buy
- ManufacturerAvaChem
- Product number6557
- Product descriptionMotolimod 98%
- Packaging25mg
- Price$295
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number6557
- Product descriptionMotolimod 98%
- Packaging5mg
- Price$80
- Updated2026-05-22
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003A5O | 2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99% | 1mg | $28 | 2026-05-28 | Buy |
| aablocks | AA003A5O | 2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99% | 2mg | $45 | 2026-05-28 | Buy |
| aablocks | AA003A5O | 2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99% | 5mg | $68 | 2026-05-28 | Buy |
| aablocks | AA003A5O | 2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99% | 10mg | $99 | 2026-05-28 | Buy |
| aablocks | AA003A5O | 2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99% | 25mg | $168 | 2026-05-28 | Buy |
| aablocks | AA003A5O | 2-Amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide 99% | 50mg | $267 | 2026-05-28 | Buy |
| ACHEMBLOCK | L13490 | VTX-2337 98% | 100MG | $405 | 2026-05-27 | Buy |
| ACHEMBLOCK | L13490 | VTX-2337 98% | 25MG | $171 | 2026-05-27 | Buy |
| ACHEMBLOCK | L13490 | VTX-2337 98% | 5MG | $68 | 2026-05-27 | Buy |
| ACHEMBLOCK | L13490 | VTX-2337 98% | 1G | $1755 | 2026-05-27 | Buy |
| AK Scientific | 2129CW | Motolimod | 1mg | $135 | 2021-12-16 | Buy |
| ApexBio Technology | B5996 | Motolimod (VTX-2337) | 5mg | $143 | 2026-05-06 | Buy |
| ApexBio Technology | B5996 | Motolimod (VTX-2337) | 10mM(in1mLDMSO) | $149 | 2026-05-06 | Buy |
| ApexBio Technology | B5996 | Motolimod (VTX-2337) | 25mg | $418 | 2026-05-06 | Buy |
| AvaChem | 6557 | Motolimod 98% | 25mg | $295 | 2026-05-22 | Buy |
| AvaChem | 6557 | Motolimod 98% | 5mg | $80 | 2026-05-22 | Buy |
Properties
Boiling point :718.7±70.0 °C(Predicted)
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :2.47±0.40(Predicted)
color :Off-white or pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-19,30H,3-6,13-16,29H2,1-2H3
InChIKey :CQAGPRVMJDWWEA-UHFFFAOYSA-N
SMILES :N4(CCCC4)C(=O)c1ccc(cc1)c2cc3c(cc2)C=C(C=C(N3)N)C(=O)N(CCC)CCC
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :2.47±0.40(Predicted)
color :Off-white or pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-19,30H,3-6,13-16,29H2,1-2H3
InChIKey :CQAGPRVMJDWWEA-UHFFFAOYSA-N
SMILES :N4(CCCC4)C(=O)c1ccc(cc1)c2cc3c(cc2)C=C(C=C(N3)N)C(=O)N(CCC)CCC
Safety Information
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Description
Motolimod is an agonist of toll-like receptor 8 (TLR8). It increases the production of TNF-α and IL-12 in human peripheral blood mononuclear cells (PBMCs; EC50s = 140 and 120 nM, respectively), monocytes, and myeloid dendritic cells. Motolimod also increases IFN-γ production in natural killer (NK) cells and increases cytolysis in K562 NK cell-sensitive leukemia cells when used at concentrations of 167 and 500 nM for 48 hours. It increases plasma levels of a group of human cytokines, including IL-6, IL-12p70, TNF-α, MCP-1, and MIP-1β, in NOD-scid IL2rynull (NSG) mice reconstituted with human immune system (NSG-HIS) when administered at doses of 1.5 and 15 mg/m2. Motolimod, when used in combination with pegylated liposomal doxorubicin (PLD), reduces tumor growth and increases tumor infiltration of monocytes and T cells in an ovarian cancer NSG-HIS mouse model.Related product price
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Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
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