ZSTK474
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- $49 - $3811.5
- Product name: ZSTK474
- CAS: 475110-96-4
- MF: C19H21F2N7O2
- MW: 417.41
- EINECS:
- MDL Number:MFCD08705334
- Synonyms:CS-438;2-(DifluoroMethyl)-1-[4,6-di(4-Morpholinyl)-1,3,5-triazin-2-yl]-1H-benziMidazole;1H-BenziMidazole, 2-(difluoroMethyl)-1-(4,6-di-4-Morpholinyl-1,3,5-triazin-2-yl)-;ZSTK474 BASE;ZSTK474/ZSTK-474;2-(difluoromethyl)-1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-1H-benzo[d]imidazole;2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine ZSTK-474;ZSTK 474 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
30 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Labseeker
- Medical Isotopes, Inc.
- TCI Chemical
- TRC
Package
- 1MG
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 2g
- 5G
- 10g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1099-M100
- Product descriptionZSTK474 ≥95%
- Packaging100mg
- Price$427
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7419
- Product descriptionZSTK474
- Packaging50mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7419
- Product descriptionZSTK474
- Packaging100mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0008609
- Product descriptionZSTK474 95.00%
- Packaging1MG
- Price$166.95
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0008609
- Product descriptionZSTK474 95.00%
- Packaging5G
- Price$3811.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8248
- Product descriptionZSTK474
- Packaging25mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60167
- Product descriptionZSTK474
- Packaging20mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546010
- Product descriptionZSTK474 >98%
- Packaging5mg
- Price$151.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546010
- Product descriptionZSTK474 >98%
- Packaging25mg
- Price$290.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146082
- Product descriptionZSTK474 >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146082
- Product descriptionZSTK474 >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146082
- Product descriptionZSTK474 >98%
- Packaging1g
- Price$1949.9
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17381
- Product descriptionZSTK474 ≥98%
- Packaging5mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17381
- Product descriptionZSTK474 ≥98%
- Packaging10mg
- Price$77
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17381
- Product descriptionZSTK474 ≥98%
- Packaging25mg
- Price$168
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17381
- Product descriptionZSTK474 ≥98%
- Packaging50mg
- Price$263
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1099-M100 | ZSTK474 ≥95% | 100mg | $427 | 2021-12-16 | Buy |
| AK Scientific | X7419 | ZSTK474 | 50mg | $84 | 2021-12-16 | Buy |
| AK Scientific | X7419 | ZSTK474 | 100mg | $114 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0008609 | ZSTK474 95.00% | 1MG | $166.95 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0008609 | ZSTK474 95.00% | 5G | $3811.5 | 2021-12-16 | Buy |
| ApexBio Technology | A8248 | ZSTK474 | 25mg | $100 | 2021-12-16 | Buy |
| Arctom | CFN60167 | ZSTK474 | 20mg | $138 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546010 | ZSTK474 >98% | 5mg | $151.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546010 | ZSTK474 >98% | 25mg | $290.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146082 | ZSTK474 >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146082 | ZSTK474 >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146082 | ZSTK474 >98% | 1g | $1949.9 | 2021-12-16 | Buy |
| Cayman Chemical | 17381 | ZSTK474 ≥98% | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 17381 | ZSTK474 ≥98% | 10mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 17381 | ZSTK474 ≥98% | 25mg | $168 | 2024-03-01 | Buy |
| Cayman Chemical | 17381 | ZSTK474 ≥98% | 50mg | $263 | 2024-03-01 | Buy |
Properties
Melting point :217-219 °C(Solv: ethanol (64-17-5))
Boiling point :640.3±65.0 °C(Predicted)
Density :1.57
storage temp. :-20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming).
form :White powder.
pka :5.21±0.10(Predicted)
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
InChIKey :HGVNLRPZOWWDKD-UHFFFAOYSA-N
SMILES :C1(C(F)F)N(C2=NC(N3CCOCC3)=NC(N3CCOCC3)=N2)C2=CC=CC=C2N=1
Boiling point :640.3±65.0 °C(Predicted)
Density :1.57
storage temp. :-20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming).
form :White powder.
pka :5.21±0.10(Predicted)
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
InChIKey :HGVNLRPZOWWDKD-UHFFFAOYSA-N
SMILES :C1(C(F)F)N(C2=NC(N3CCOCC3)=NC(N3CCOCC3)=N2)C2=CC=CC=C2N=1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||
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Description
ZSTK474 is a triazine derivative that acts as an inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms (IC50s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). It is selective for PI3K, as it has negligible activity against 139 other kinases when tested at 30 μM. ZSTK474 is orally bioavailable and shows strong antitumor activity against human cancer xenografts in mice. The efficacy of ZSTK474 against certain cancer cells and tumors can be enhanced by combination therapy.More related product prices
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