14,15-LEUKOTRIENE C4

14,15-LEUKOTRIENE C4 Struktur
75290-60-7
CAS-Nr.
75290-60-7
Englisch Name:
14,15-LEUKOTRIENE C4
Synonyma:
EXC4;EOXIN C4;14,15-LTC4;14,15-LEUKOTRIENE C4;OBQVBASHEWLKCQ-PKBWNXTMSA-N;Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
CBNumber:
CB0196624
Summenformel:
C30H47N3O9S
Molgewicht:
625.77
MOL-Datei:
75290-60-7.mol

14,15-LEUKOTRIENE C4 Eigenschaften

storage temp. 
Store at -20°C
Löslichkeit
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 100 μg/ml
Aggregatzustand
Liquid.

Sicherheit

14,15-LEUKOTRIENE C4 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.

Verwenden

14,15-Leukotriene C4 is an acute inflammatory mediator.

14,15-LEUKOTRIENE C4 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


14,15-LEUKOTRIENE C4 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 26)Lieferanten
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Aladdin Scientific
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
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Shanghai Hongye Biotechnology Co. Ltd 400-9205774
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Energy Chemical 021-58432009 400-005-6266
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