5-Hydroxyindol-3-ylessigsure
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- CAS-Nr.
- 54-16-0
- Bezeichnung:
- 5-Hydroxyindol-3-ylessigsure
- Englisch Name:
- 5-HYDROXYINDOLE-3-ACETIC ACID
- Synonyma:
- 5-HIAA;HIAA;2-(5-hydroxy-1H-indol-3-yl)acetic acid;5-oxyindoleaceticacid;5-HYDROXY-3-INDOLEACETIC ACID;5&＃039;5-HO-IAA;NSC 90432;Nature Product;TIMTEC-BB SBB003639
- CBNumber:
- CB0362913
- Summenformel:
- C10H9NO3
- Molgewicht:
- 191.18
- MOL-Datei:
- 54-16-0.mol
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5-Hydroxyindol-3-ylessigsure Eigenschaften
- Schmelzpunkt:
- 161-164 °C (dec.) (lit.)
- Siedepunkt:
- 326.92°C (rough estimate)
- Dichte
- 1.2722 (rough estimate)
- Brechungsindex
- 1.5310 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- Soluble in ethanol (50 mg/ml).
- pka
- 4.54±0.30(Predicted)
- Aggregatzustand
- crystalline
- Farbe
- off-white to purple
- Sensitive
- Light Sensitive
- BRN
- 168797
- Stabilität:
- Air Sensitive, Light Sensitive
- InChIKey
- DUUGKQCEGZLZNO-UHFFFAOYSA-N
- CAS Datenbank
- 54-16-0
5-Hydroxyindol-3-ylessigsure Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
5-hydroxy Indole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT; ). It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for detection of neuroendocrine tumors and an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. 5-HIAA has also been associated with autism, insomnia, and chronic migraine.
Chemische Eigenschaften
beige crystalline powder
Verwenden
5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.
Definition
ChEBI: A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Allgemeine Beschreibung
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Mechanism of action
The primary
product of the metabolism of serotonin. Formed by the oxidative
deamination of serotonin by monoamine oxidase, presumably
the A isozyme, 5-HIAA is subsequently cleared by an
active transport mechanism. Unlike serotonin, 5-HIAA is not a
neurotransmitter and thus its formation contributes to the termination
of the synaptic actions of serotonin. Inhibition of
monoamine oxidase activity enhances and prolongs the actions
of serotonin.
5-Hydroxyindol-3-ylessigsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Hydroxyindol-3-ylessigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 163)Lieferanten
54-16-0(5-Hydroxyindol-3-ylessigsure)Verwandte Suche:
- TIMTEC-BB SBB003639
- HYDROXYINDOLYL-3-ACETIC ACID, 5-
- 5-hydroxyindol-3-ylacetic acid
- 5-HYDROXYINDOLE-3-ACETIC ACID FREE ACID
- 5-Hydroxy-3-indolyl acetic acid
- 1H-Indole-3-acetic acid, 5-hydroxy-
- Hydroxyindoleacetic Acid
- 5-HYDROXYINDOLE-3-ACETIC ACID
- 5-HYDROXYINDOLYACETIC ACID
- 5-HYDROXYINDOLYL-3-ACETIC ACID
- (5-HYDROXY-1H-INDOL-3-YL)-ACETIC ACID
- 5-hydroxy-1h-indole-3-aceticaci
- 5-hydroxyheteroauxin
- 5-hydroxyindoleaceticacid
- 5-hydroxyindolylaceticacid
- 5-HYDROXYINDOLE-3-ACETIC ACID 99%
- 5-HO-IAA
- Tryptophan Metabolite (HIAA)
- NSC 90432
- 5-Hydroxy-1H-indole-3-acetic acid
- 5-HYDROXYINDOLE-3-ACETIC ACID(5OHIAA)
- 5-Hydroxyindole-3-acetic acid,99%
- 5-Hydroxyindole-3-acetic acid,5-HIAA
- Tryptophan Impurity 15
- Nature Product
- 5-Hydroxyindole-3-acetic Acid (Solution)
- 5-Hydroxyindole-3-aceticAcid>
- 5-Hydroxyindoleacetic Acid (5HIAA) (Solution)
- 5-HYDROXYINDOLE-3-ACETIC ACID UNLABELED 100 UG/ML IN METHANOL
- 5-Hydroxyindo 1e-3-acetic acid
- (5-hydroxyindol-3-yl)aceticaci
- 2-(5-hydroxy-1H-indol-3-yl)acetic acid
- 5-oxyindoleaceticacid
- 5-HYDROXY-3-INDOLEACETIC ACID
- 5-HIAA
- HIAA
- 2H5]-5-Hydroxyindoleacetic acid
- inhibit,5HYDROXYINDOLE3ACETIC ACID,Inhibitor,Endogenous Metabolite,5 HYDROXYINDOLE 3 ACETIC ACID
- 5&＃039
- -Hydroxyindole-3-acetic acid
- 54-16-0
- HOC8H5NCH2COOH
- Indoles
- Simple Indoles
- Indoles
- Simple Indoles
