Ammoniumglycyrrhizinat

Glycyrrhizic acid ammonium salt Struktur
53956-04-0
CAS-Nr.
53956-04-0
Bezeichnung:
Ammoniumglycyrrhizinat
Englisch Name:
Glycyrrhizic acid ammonium salt
Synonyma:
MONOAMMONIUM GLYCYRRHIZINATE;Magnasweet;monoammoniumglycyrrhizate;glycyrrhizin monoammonium salt;Monoammonium Glycyrrhizinate S;GLYCYRRHIZINATE MONOAMMONIUM SALT;GLYCYRRHIZIC ACID MONOAMMONIUM SALT;GLYCAMIL;icorice);t from g
CBNumber:
CB1492372
Summenformel:
C42H65NO16
Molgewicht:
839.97
MOL-Datei:
53956-04-0.mol

Ammoniumglycyrrhizinat Eigenschaften

Schmelzpunkt:
>200°C (dec.)
Siedepunkt:
768.56°C (rough estimate)
Dichte
1.1846 (rough estimate)
FEMA 
2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
Brechungsindex
49 ° (C=1.5, EtOH)
storage temp. 
2-8°C
Löslichkeit
Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.
Aggregatzustand
Powder or Crystals
Farbe
Yellow to yellow-green
Geruch (Odor)
bland
Optische Aktivität
[α]20/D +48±4°, c = 1% in ethanol: water (1:1)
BRN 
3897076
Stabilität:
Hygroscopic
InChIKey
ILRKKHJEINIICQ-YDYGGSECSA-N
LogP
-0.9
CAS Datenbank
53956-04-0
EPA chemische Informationen
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  UN 3077 9 / PGIII
WGK Germany  2
RTECS-Nr. LZ6500000
3-10
HS Code  29389090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Ammoniumglycyrrhizinat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.

Chemische Eigenschaften

white to slightly yellow powder

Verwenden

Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.

Allgemeine Beschreibung

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Anticancer Research

Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.

Sicherheitsprofil

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.

läuterung methode

Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]

Ammoniumglycyrrhizinat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ammoniumglycyrrhizinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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53956-04-0(Ammoniumglycyrrhizinat)Verwandte Suche:


  • monoammoniumglycyrrhetat
  • Monoammoniumglycyrrhetate
  • (2S,3S,4S,5R,6S)-6-[[(3S,4aS,6aR,6bS,8aR,11S,12aR,14aS,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylic acid azane
  • alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en- 3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate
  • 20β-Carboxy-11-oxo-30-noroleana-12-ene-3β-yl 2-O-(β-D-glucopyranuronosyl)-α-D-glucopyranosiduronic acid/ammonia,(1:x)
  • Glycyrrhizine ammonium salt
  • AMMONIUM 10-[6-CARBOXY-3-(6-CARBOXY-3,4,5-TRIHYDROXY-OXAN-2-YL)OXY-4,5-DIHYDROXY-OXAN-2-YL]OXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-3,4,5,6,6A,7,8,8A,10,11,12,14B-DODECAHYDRO-1H-PICENE-2-CARBOXYLATE
  • AMMONIATED GLYCYRRHIZIN
  • 3-O-(2-O-BETA-D-GLUCOPYRANURONOSYL-ALPHA-D-GLUCOPYRANURONOSYL)-18BETA-GLYCYRRHETINIC ACID AMMONIUM SALT
  • GLYCAMIL
  • GLYCYRRHIZIC ACID AMMONIUM SALT
  • GLYCYRRHIZIC ACID, NH4
  • GLYCYRRHIZIC ACID, NH4+
  • GLYCYRRHIZIN AMMONIACAL
  • GLYCYRRHIZIN, AMMONIATED
  • GLYCYRRHIZIN AMMONIUM SALT
  • Glycyrrhizic acid monoammonium salt trihydrate,98%
  • GLYCYRRHIZIC ACID, AMMONIUM SALT(RG)
  • Glycyrrhiz
  • Glycyrrhizic acid, aMMoniuM salt, trihydrate / Glycyrrihizin
  • Glycyrrhizic acid MonoaMMoniuM salt, 98+%
  • Glycyrrhizic acid MonoaMMoniuM salt trihydrate, 98% 25GR
  • aMMoniuM (2S,3S,4S,5R,6S)-5-((2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yloxy)-6-((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydrop
  • Glycyrrhizic Acid Monoammonium Salt Glycyrrhizin Monoammonium Salt
  • MonoaMMoniuM 18β-glycyrrhizinate
  • MONOAMMONIATED GLYCYRRHIZINATE
  • MONOAMMONIUM GLYCRRHIZINATE
  • .alpha.-D-Glucopyranosiduronicacid,(3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl2-O-.beta.-D-glucopyranuronosyl-,monoammoniumsalt
  • ammoniate
  • Ammoniumglycynhizinato
  • ammoniumglycyrrhizate
  • glycyrram
  • .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt
  • GLYCYRRHIZINICACIDAMMONIUMSALT
  • GLYCERRHIZICACIDMONOAMMONIUMSALT
  • GLYCYRRHIZICAMMONIUM
  • AMMONIUMGLYCYRRHIZIN
  • AMMONIATEDGLYCERRHIZIN
  • (2S,3S,4S,5R,6S)-6-[[(3S,4aS,6aR,6bS,8aR,11S,12aR,14aS,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxy-3,4-dihydroxy-oxane-2-carboxylic acid
  • MONOAMMONIUM GLYCYRRHIZINATE 95% SODIUM GLYCYRRHIZINTE 95%
  • α-D-Glucopyranosiduronic acid, (3,20)-20-carboxy- 11-oxo-30-norolean-12-en-3-yl 2-O--D-glucopyranuronosyl-, monoammonium salt
  • 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid ammonium salt
  • GLYCYRRHIZIN, AMMONIATED [GLYCYRRHIZINIC ACID, MONOAMMONIUM SALT]
  • GLYCYRRHIZIC ACID AMMONIUM
  • GlycyrrhizinicAcidAmmoniumSalt,>95%
  • 3-O-(2-O-beta-D-Glucopyranuronosyl-alpha-D-glucopyranuronosyl)-18beta-g lycyrrhetinic acid ammonium salt
  • AMMONIATED GLYCYRRHIZIN, NATURAL
  • Mono aMMoniuM glycrrnhizinate
  • Glycyrrhizic acid aMMoniuM salt EP/BP
  • Glycyrrhizic acid aMMoniuM salt, froM Glycyrrhizae
  • a-D-Glucopyranosiduronic acid, (3b,20b)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-b-D-glucopyranuronosyl-, aMMoniuMsalt (1:1)
  • Glycyrrhizic acid aMMoniuM salt froM glycyrrhiza root (licorice) >=70% (HPLC)
  • Ammonium Glyeyrrhizinate
  • Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice)
  • Ammonium Glycyrrhizate (100 mg)
  • Glycyrrhizic acid ammonium salt, >=73%
  • Glycyrrhizin Acid Ammonium Salt
  • GLYCYRRHIZIC ACID AMMONIUM SALT FROM
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