2,2'-[(1-Methylethyliden)bis(4,1-phenylenoxymethylen)]bisoxiran Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
GERUCHLOSE, GELBLICHBRAUNE, VISKOSE FLüSSIGKEIT.
CHEMISCHE GEFAHREN
Bildung explosionsfähiger Peroxide wahrscheinlich. Reagiert mit starken Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK: Hautresorption; Sensibilisierung der Haut; Krebserzeugend Kategorie 3A; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt die Augen und die Haut. Exposition könnte Bewusstseinstrübung verursachen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Hautkontakt kann zu Dermatitis und Hautsensibilisierung führen.
LECKAGE
Belüftung. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit viel Wasser wegspülen. Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe.
R-Sätze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Most epoxy resins result from polymerization of
bisphenol A diglycidyl ether (BADGE). Delayed hypersensitivity
is caused by the low-molecular-weight
monomer BADGE (MW 340 g/mol), the dimer having
a much lower sensitization power. This allergen caused
contact dermatitis in six workers in a plant producing
printed circuits boards made of copper sheets and
fiberglass fabric impregnated with a brominated epoxy
resin. It can also be contained in adhesives.
Chemische Eigenschaften
Diglycidyl ether of bisphenol A is a colorless to light amber liquid. Slight epoxy odor.
Verwenden
Bisphenol A derivative. A PPARγ antagonist; exhibits estrogenic activity; An inhibitor of PPARγ and suppressor of TNFα.
Vorbereitung Methode
The synthesis of the basic epoxy resin molecule involves the
reaction of epichlorohydrin with bisphenol A, the latter
requiring two basic intermediates for synthesis, acetone
and phenol. Theoretically, the production of the bisphenol
A diglycidyl ether requires 2 mol of epichlorohydrin for each
mole of the phenol.
Epoxy resins of higher molecular weight are obtained by
reducing the epichlorohydrin/bisphenol A ratio. This reaction
involves consumption of the initial epoxy groups in the
epichlorohydrin and of some of the groups formed by
dehydrohalogenation.
Allgemeine Beschreibung
Odorless yellowish brown liquid. Sinks in water.
Air & Water Reaktionen
Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. Insoluble in water.
Reaktivität anzeigen
Epoxides, such as BISPHENOL A DIGLYCIDYL ETHER RESIN, are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.
Health Hazard
Contact with liquid irritates eyes. Prolonged or repeated contact with skin causes irritation and dermatitis.
Brandgefahr
BISPHENOL A DIGLYCIDYL ETHER RESIN is probably combustible.
Biologische Aktivität
PPAR γ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPAR δ and PPAR α . Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPAR γ . Acts as a PPAR γ agonist in an ECV304 cell line. Also produces PPARg-independent apoptosis of tumor cells via several mechanisms. Active in vivo .
Kontakt-Allergie
Most epoxy resins result from polymerization of bisphenol
A diglycidyl ether (BADGE). Delayed hypersensitivity
is caused by the low-molecular-weight
monomer BADGE (Molecular Weight 340 g/mol),
the dimer having much a lower sensitization power.
This allergen caused contact dermatitis in six workers
in a plant producing printed circuits boards made
of copper sheets and fiber glass fabric impregnated
with a brominated epoxy resin. It can be contained in
adhesives.
mögliche Exposition
Diglycidyl ether of bisphenol A is used as a basic active ingredient of epoxy resins.
Carcinogenicity
In summary, a number of carcinogenicity studies involving
the topical application of pure BADGE as well as EPON
Resin 828 and other commercial BADGE-based resins have
been carried out in experimental animals.Viewing the studies
as a whole, the weight of evidence does not show that
BADGE or BADGE-based epoxy resins are carcinogenic.
Inkompatibilitäten
Easily oxidized in air; presumed to form unstable and explosive peroxides in storage. Incompatible with strong acids; strong oxidizers.
Waste disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
2,2'-[(1-Methylethyliden)bis(4,1-phenylenoxymethylen)]bisoxiran Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
