ChemicalBook >> CAS DataBase List >>N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE structure

CAS No.: 127408-30-4

Chemical Name:: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE

Synonyms: Y-27152;Y 27152,Y27152;N-(Benzyloxy)-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)acetamide;N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE;N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE;Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)-

CBNumber:: CB1837188

Molecular Formula:: C21H22N2O4

Molecular Weight:: 366.41

MDL Number:: MFCD00899866

MOL File:: 127408-30-4.mol

Last updated:2023-05-18 11:31:09

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N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Properties

Boiling point	513.4±60.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	Soluble to 5 mM in ethanol with gentle warming and to 25 mM in DMSO
form	Powder
pka	13.18±0.60(Predicted)
FDA UNII	3XM5F7WR44

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	257140	Y-27152	127408-30-4	10mg	$508	2021-12-16	Buy
TRC	Y120018	Y-27152	127408-30-4	50mg	$875	2021-12-16	Buy
American Custom Chemicals Corporation	INB0003910	N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE 95.00%	127408-30-4	5MG	$496.6	2021-12-16	Buy
AHH	MT-06917	N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1benzopyran-4-yl]-N-(phenylmethoxy)acetamide 98%	127408-30-4	0.05g	$536	2021-12-16	Buy

Product number	Packaging	Price	Buy
257140	10mg	$508	Buy
Y120018	50mg	$875	Buy
INB0003910	5MG	$496.6	Buy
MT-06917	0.05g	$536	Buy

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Chemical Properties,Uses,Production

Uses

Y-27152, is a prodrug of the Kir6 (KATP) channel opener. It has also shown to produce antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Definition

ChEBI: N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-N-phenylmethoxyacetamide is a 1-benzopyran.

Biological Activity

Prodrug of the K ATP channel opener Y-26763 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide ). Inactive in vitro ; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. In vivo, produces long-lasting antihypertensive effects with minimal tachycardia following oral administration in hypertensive animals.

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Suppliers

Global( 35)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9634	58
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	6000	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9633	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.	027-65388397 18164111589	3321478047@qq.com	China	1995	55
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
BOC Sciences	--	info@bocsci.com	USA	0	65

Supplier	Advantage
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
Finetech Industry Limited	58
Nanjing Bicbiotechnology Co., Ltd	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Finetech Industry Limited	58
EMMX Biotechnology LLC	60
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.	55
Fan De(Beijing) Biotechnology Co., Ltd.	58
BOC Sciences	65

127408-30-4(N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE)Related Search:

6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE 4-isopropoxybenzonitrile 3-CYANOBENZYLAMINE Benzenemethanamine, 2-(1-methylethoxy)- (9CI) 3-(methylaminomethyl)benzonitrile

3-M-TOLYL-DL-BETA-ALANINOL N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE 4-TERT-BUTOXYBENZONITRILE 2-(3-CYANO-PHENYL)ETHANOL N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

4-(2-hydroxyethoxy)benzonitrile D(-)-AC-ALPHA-PHENYLGLYCINOL 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI) (S)-1-Phenylethylhydroxylamine (S)-3-(1-Aminoethyl)benzonitrile

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N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Y-27152 N-(Benzyloxy)-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)acetamide Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)- N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Y 27152,Y27152 127408-30-4 Potassium channel