ChemicalBook >> CAS DataBase List >>N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE structure

CAS No.: 127408-31-5

Chemical Name:: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

Synonyms: Y-26763;Y 26763,Y26763;N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE;Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy-

CBNumber:: CB7841565

Molecular Formula:: C14H16N2O4

Molecular Weight:: 276.29

MDL Number:: MFCD00888284

MOL File:: 127408-31-5.mol

Last updated:2023-06-30 15:45:59

Request For Quotation

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Properties

Boiling point	455.4±55.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	Soluble to 100 mM in 1eq. NaOH
form	Powder
pka	8.69±0.60(Predicted)
FDA UNII	Q9F3XV8A6X

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21459	Y-26763	127408-31-5	1mg	$37	2024-03-01	Buy
Cayman Chemical	21459	Y-26763	127408-31-5	5mg	$116	2024-03-01	Buy
Cayman Chemical	21459	Y-26763 ≥98%	127408-31-5	10mg	$213	2024-03-01	Buy
Tocris	2076	Y-26763 ≥98%(HPLC)	127408-31-5	10	$210	2021-12-16	Buy
Tocris	2076	Y-26763 ≥98%(HPLC)	127408-31-5	50	$840	2021-12-16	Buy

Product number	Packaging	Price	Buy
21459	1mg	$37	Buy
21459	5mg	$116	Buy
21459	10mg	$213	Buy
2076	10	$210	Buy
2076	50	$840	Buy

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Chemical Properties,Uses,Production

Uses

Y-26763, is a Kir6 (KATP) channel opener. It also inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. In vivo, it has shown to have hypotension activity in rats and cardioprotective properties in dogs.

Definition

ChEBI: N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-N-hydroxyacetamide is a 1-benzopyran.

Biological Activity

K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration.

storage

Store at RT

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Suppliers

Global( 44)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
Jiangsu aikang biomedical research and development co., LTD	025-66110311 13155353615	qzhang@aikonchem.com	China	15527	58
Shanghai Anhua Biotechnology Co., Ltd.	021-61263375 18168859245		China	5958	58
Wuxi maimo topp biotechnology co., LTD	15061806929	linda-fu@mimotopes.cn	China	5853	58

Supplier	Advantage
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
BOC Sciences	65
EMMX Biotechnology LLC	60
Fan De(Beijing) Biotechnology Co., Ltd.	58
Jiangsu aikang biomedical research and development co., LTD	58
Shanghai Anhua Biotechnology Co., Ltd.	58
Wuxi maimo topp biotechnology co., LTD	58

127408-31-5(N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE)Related Search:

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3-M-TOLYL-DL-BETA-ALANINOL (S)-1-Phenylethylhydroxylamine 3-(methylaminomethyl)benzonitrile (S)-3-(1-Aminoethyl)benzonitrile 4-TERT-BUTOXYBENZONITRILE

3-CYANOBENZYLAMINE 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE 4-isopropoxybenzonitrile Benzenemethanamine, 2-(1-methylethoxy)- (9CI) 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI)

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE D(-)-AC-ALPHA-PHENYLGLYCINOL N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

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N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y-26763 Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy- Y 26763,Y26763 127408-31-5 C14H16N2O4 Potassium channel