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| Product Name: | ACA | | Synonyms: | N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID;4-amylcinnamoylanthranilicacid;2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID;N-(p-Amylcinnamoyl) anthranilic Acid (ACA);ACA;2-(3-(4-Pentylphenyl)acrylamido)benzoic acid;Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-;N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor | | CAS: | 110683-10-8 | | MF: | C21H23NO3 | | MW: | 337.41 | | EINECS: | | | Product Categories: | | | Mol File: | 110683-10-8.mol |  |
| Melting point | 172-174℃ | | Boiling point | 563.1±50.0 °C(Predicted) | | density | 1.178±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly, Heated), Methanol (Slightly) | | pka | 3.49±0.36(Predicted) | | form | White solid. | | color | White to Off-White |
| Uses | N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM. | | Definition | ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide. | | references | harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6. |
| | ACA Preparation Products And Raw materials |
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