| Company Name: |
Wuxi AppTec
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| Tel: |
022-59987777 13552403979 |
| Email: |
jia_guoqiang@wuxiapptec.com |
| Products Intro: |
Product Name:(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid
CAS:99754-06-0
Purity:95%+ Package:1G,5G,10G,25G,50G,100G,250G Remarks:in stock
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| Company Name: |
Aikon International Limited
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| Tel: |
025-66113011 18112977050 |
| Email: |
cb6@aikonchem.com |
| Products Intro: |
Product Name:2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
CAS:99754-06-0
Purity:95% HPLC or GC Package:10G,5G;1G
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| | 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Basic information |
| Product Name: | 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID | | Synonyms: | 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID;ONO-RS-082;2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid;2-[[(E)-4-Pentylcinnamoyl]amino]-4-chlorobenzoic acid sodium salt;4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid;(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid;(E)-4-chloro-2-(3-(4-pentylphenyl)acrylamido)benzoic acid(WXC06363);4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid | | CAS: | 99754-06-0 | | MF: | C21H22ClNO3 | | MW: | 371.86 | | EINECS: | | | Product Categories: | | | Mol File: | 99754-06-0.mol |  |
| | 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Chemical Properties |
| Melting point | 175-177℃ | | storage temp. | room temp | | solubility | DMSO: ≥20mg/mL | | form | powder | | color | white | | Sensitive | Light Sensitive | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 2 | | HazardClass | 9 |
| | 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Usage And Synthesis |
| Description | ONO-RS-082 (99754-06-0) is a reversible inhibitor of Ca2+-independent phospholipase A2?(PLA2), IC50=7 μM for guinea pig lung PLA2.1?Inhibits epinephrine-induced thromboxane production in platelets.1?Inhibition of PLA2?by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4?Prevents Xenopus oocyte maturation at stage V.5 | | Uses | ONO-RS-082 is a potent PLA2 and epinephrine inhibitor.ONO-RS-082 is a phospholipase inhibitor. | | in vitro | previous study found that human platelets stimulated by epinephrine led to enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulated inositol trisphosphate, diacylglycerol, and phosphatidic acid, indicating stimulation of phospholipase c. it was shown that these responses could be completely blocked by inhibitors of alpha 2-adrenergic receptors including ono-rs-082 or removal of fibrinogen. in addition, epinephrine could evoked an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that was inhibited by ono-rs-082 or the absence of fibrinogen. moreover, it was found that ono-rs-082 at 3.5 μm was able to inhibit epinephrine-stimulated thromboxane production in human platelets. ono-rs-082 could also disrupt endosome tubule formation and maintenance of the golgi complex [1]. | | References | 1) Banga?et al.?(1986),?Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA?83?9197
2) De Figueiredo?et al. (2001),?Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem.?276?47361
3) Schmidt?et al. (2010),?A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic?11?1530
4) Bechler and Brown (2014),?Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol.?28?0004
5) Islam?et al.?(2005),?The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal.?17?507 |
| | 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Preparation Products And Raw materials |
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