ChemicalBook CAS DataBase List 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol

4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol synthesis

5synthesis methods

Product Name:4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol
CAS Number:1429757-65-2
Molecular formula:C15H10Cl2FN3O2
Molecular Weight:354.16

574745-97-4 Synthesis

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4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol

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Yield: 78%

Reaction Conditions:

with water in water;isopropyl alcohol for 6 h;Reflux;

Steps:

77.1 4-((3,4-Dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
Combine 4-chloro-7-methoxyquinazolin-6-ol (2.11g, 10.0mmol), 3,4-dichloro-2-fluoroaniline (2.70g, 15.0mmol) and concentrated hydrochloric acid (1 drop) Add isopropanol (50 mL) and reflux for 6 hours. The reaction solution was cooled, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to obtain the product 4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6- Alcohol (Intermediate 77-1, 2.75 g, Yield: 78%).

References:

Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.;Jiangsu Haosen Pharmaceutical Group Co., Ltd.;Wang Feng;Li Kailong;Huang Zhiqiang;Cai Jiaqiang CN112079830, 2020, A Location in patent:Paragraph 0841-0847

1429757-64-1 Synthesis