| Identification | Back Directory | [Name]
3-Pyrrolidinecarboxamide, N-(7-chloro-1,2-dihydro-1-oxo-6-isoquinolinyl)-4-(4-chlorophenyl)-, (3R,4S)-rel- | [CAS]
1013117-40-2 | [Synonyms]
ROCKIN32
ROCK-IN-32
ROCK IN 32
ROCK inhibitor 32
ROCK-inhibitor-32
3-Pyrrolidinecarboxamide, N-(7-chloro-1,2-dihydro-1-oxo-6-isoquinolinyl)-4-(4-chlorophenyl)-, (3R,4S)-rel- | [Molecular Formula]
C20H17Cl2N3O2 | [MOL File]
1013117-40-2.mol | [Molecular Weight]
402.27 |
| Hazard Information | Back Directory | [Description]
ROCK-IN-32 is a potent Rho--?kinase (ROCK) inhibitor. | [Uses]
ROCK-IN-32 is a ROCK inhibitor, with an IC50 value of 11 nM for ROCK2. ROCK-IN-32 can be used in research of cardiovascular disease, cancer and inflammation[1]. | [References]
[1] Bosanac T, et al. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3746-9. DOI:10.1016/j.bmcl.2010.04.069 |
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