| Identification | More | [Name]
ISOPROPYLSULFONYL CHLORIDE | [CAS]
10147-37-2 | [Synonyms]
2-PROPANESULFONYL CHLORIDE
2-PROPANESULPHONYL CHLORIDE
ISOPROPYLSULFONYL CHLORIDE
ISOPROPYLSULPHONYL CHLORIDE
PROPANE-2-SULFONYL CHLORIDE
Isopropylsulphonyl choride
1-Methylethanesulfonic acid chloride
1-Methylethanesulfonyl chloride
Propane-2-sulfonic acid chloride | [EINECS(EC#)]
233-415-2 | [Molecular Formula]
C3H7ClO2S | [MDL Number]
MFCD00007453 | [Molecular Weight]
142.6 | [MOL File]
10147-37-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear pale yellow-greenish liquid | [Melting point ]
-47°C | [Boiling point ]
74-75 °C/19 mmHg (lit.) | [density ]
1.27 g/mL at 25 °C(lit.)
| [vapor density ]
4 (vs air)
| [vapor pressure ]
15.5 mm Hg ( 25 °C)
| [refractive index ]
n20/D 1.453(lit.)
| [Fp ]
187 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Acetontrile (Slightly), Chloroform (Slightly) | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [Specific Gravity]
1.270 | [Water Solubility ]
Reacts with water. | [Sensitive ]
Lachrymatory | [BRN ]
1747497 | [CAS DataBase Reference]
10147-37-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [F ]
13-19-21 | [Autoignition Temperature]
865 °F | [Hazard Note ]
Lachrymatory/Corrosive | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29049090 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear pale yellow-greenish liquid | [Uses]
2-Propanesulfonyl chloride (isopropylsulfonyl chloride) can be used as a reactant to prepare:
- 1-Isopropylsulfonyl-2-amine benzimidazole by reacting with 2-aminobenzimidazole via N-sulfonylation reaction in the presence of a base.
- Bis(isopropylsulfonyl)disulfide, a sulfurizing agent, used to synthesize phosphorothioate oligonucleotide analogs.
| [Uses]
2-Propanesulfonyl chloride is used as a pharmaceutical intermediate. Reductive cleavage of a secondary alcohol to methylene has been achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride. | [General Description]
The solvolysis of 2-propanesulfonyl chloride by an addition-elimination (association-dissociation) pathway was studied. |
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