| Identification | More | [Name]
N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE | [CAS]
287953-54-2 | [Synonyms]
1-PIPERIDINECARBOXYLIC ACID, 4-(CHLOROSULFONYL)-,PHENYLMETHYL ESTER
4-CHLOROSULFONYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
Benzyl 4-(chlorosulfonyl)tetrahydro-1(2H)-pyridinecarboxylate
N-BENZOYLOXYCARBONYL-4-PIPERIDINE SULFONYL CHLORIDE
N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE
N-(BENZYLOXYCARBONYL)-PIPERIDINE-4-SULPHONYL CHLORIDE
N-CBZ-4-PIPERIDINE SULFONYL CHLORIDE
PIPERIDINE-4-SULFONYL CHLORIDE, N-CBZ PROTECTED
Piperidine-4-sulphonyl chloride, N-CBZ protected
benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate | [Molecular Formula]
C13H16ClNO4S | [MDL Number]
MFCD05664659 | [Molecular Weight]
317.79 | [MOL File]
287953-54-2.mol |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of N-Benzyloxycarbonyl-4-piperidinesulfonyl chloride from benzyl 4-(acetylthio)piperidine-1-carboxylate: Benzyl 4-(acetylthio)piperidine-1-carboxylate (1.45 g, 4.94 mmol) was dissolved in a mixed solvent of dichloromethane (10 mL) and water (40 mL), and the reaction was stirred for 4 hours at 0 °C, while chlorine was passed through the reaction. After completion of the reaction, the organic layer was separated and the aqueous layer was extracted with dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to afford benzyl 4-(chlorosulfonyl)-1-piperidinecarboxylate (1.58 g, 100% yield). | [References]
[1] Patent: EP1403255, 2004, A1. Location in patent: Page 90
[2] Synthesis, 2011, # 22, p. 3669 - 3674
[3] Patent: WO2003/103669, 2003, A1. Location in patent: Page 44-45 |
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