| Identification | More | [Name]
Fmoc-D-proline | [CAS]
101555-62-8 | [Synonyms]
9-FLUORENYLMETHOXYCARBONYL-D-PROLINE
FMOC-D-PRO
FMOC-D-PROLINE
FMOC-D-PRO-OH
FMOC-D-PRO-OH H2O
FMOC-D-PYRD(2)-OH
N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLINE
N-(9-FLUORENYLMETHOXYCARBONYL)-D-PYRROLIDINE-2-CARBOXYLIC ACID
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLINE
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-PROLINE
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-PROLINE MONOHYDRATE
N-ALPHA-FMOC-D-PROLINE
(R)-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-(9H-FLUOREN-9-YLMETHYL) ESTER
n-[(9h-fluoren-9-ylmethoxy)carbonyl]-d-proline
n-fmoc-d-proline
FMOC-D-
(R)-PYRROLIDINE-1,2-DICARBOXYLIC ACID
1-(9H-FLUOREN-9-YLMETHYL) ESTER
N-Fmoc-D-proline, 98+%, may cont. up to ca 5% water
FMOC-D-PROLINE extrapure | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C20H19NO4 | [MDL Number]
MFCD00065671 | [Molecular Weight]
337.37 | [MOL File]
101555-62-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
110-116°C | [Boiling point ]
548.6±43.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [refractive index ]
32 ° (C=1, DMF) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder to crystal | [pka]
3.95±0.20(Predicted) | [color ]
White to Light yellow | [Optical Rotation]
[α]/D +31.0±3.0°, c = 1 in DMF | [Detection Methods]
T,NMR,Rotation | [BRN ]
5856698 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C20H19NO4/c22-19(23)18-10-5-11-21(18)20(24)25-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17-18H,5,10-12H2,(H,22,23)/t18-/m1/s1 | [InChIKey]
ZPGDWQNBZYOZTI-GOSISDBHSA-N | [SMILES]
N1(C(OCC2C3=C(C=CC=C3)C3=C2C=CC=C3)=O)CCC[C@@H]1C(O)=O | [CAS DataBase Reference]
101555-62-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
In organic synthesis, N-Fmoc-D-proline are often employed as important intermediates in various areas such as peptide synthesis, asymmetric synthesis, medicinal chemistry, and polymer chemistry. | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis | [Synthesis]
D-proline was added to a round-bottomed flask, 10% aqueous sodium carbonate was added and stirred to dissolve, then dioxane was added, and a 10% dioxane solution of 9-fluorenylmethoxycarbonyl chloride was slowly added dropwise into the reaction solution u |
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