| Identification | More | [Name]
Fmoc-D-phenylalanine | [CAS]
86123-10-6 | [Synonyms]
9-FLUORENYLMETHOXYCARBONYL-D-PHENYLALANINE
FMOC-D-PHE
FMOC-D-PHENYLALANINE
FMOC-D-PHE-OH
N-(9-FLUORENYLMETHOXYCARBONYL)-D-PHENYLALANINE
N-(9-FLUOROENYLMETHOXYCARBONYL)-D-PHENYLALANINE
N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-D-PHENYLALANINE
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-PHENYLALANINE
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-PHENYLALANINE
N-ALPHA-FMOC-D-PHENYLALANINE
N-FMOC-D-PHENYLALANINE
(R)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID
FmocAV21690
Fmoc-D-Phc-OH
FMOC-D-Phenylalanine-OH
FMOC-D-PHENYLALANINE 99%
N-(9-Fluorenylmethoxycarbonyl)
(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropanoic acid
FMOC-D-PHENYLALANINE extrapure
N-fluorenylmethoxycarbonyl-D-phenylalanine | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C24H21NO4 | [MDL Number]
MFCD00062955 | [Molecular Weight]
387.43 | [MOL File]
86123-10-6.mol |
| Questions And Answer | Back Directory | [Synthesis]
The conventional synthetic method for 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one begins with 2-amino-3-benzyloxypyridine. A one-step condensation reaction with phosphine oxychloride yields the target product with a benzyl-protected hydroxyl group. The benzyl group is then removed under palladium-carbon hydrogenation to obtain 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one. It is worth noting that a hydrogen pressure of one atmosphere is sufficient for the palladium-carbon hydrogenation process, and heating conditions can yield better reaction results. 
|
| Chemical Properties | Back Directory | [Melting point ]
181-185°C | [Boiling point ]
620.1±50.0 °C(Predicted) | [density ]
1.276±0.06 g/cm3(Predicted) | [refractive index ]
38 ° (C=1, DMF) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder or Crystalline Powder | [pka]
3.77±0.10(Predicted) | [color ]
White | [Optical Rotation]
39°(C=0.01 g/mI, DMF, 20°C, 589nm) | [Detection Methods]
T,NMR,Rotation | [BRN ]
4767931 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C24H21NO4/c26-23(27)22(14-16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h1-13,21-22H,14-15H2,(H,25,28)(H,26,27)/t22-/m1/s1 | [InChIKey]
SJVFAHZPLIXNDH-JOCHJYFZSA-N | [SMILES]
C(O)(=O)[C@@H](CC1=CC=CC=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O | [CAS DataBase Reference]
86123-10-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
N-Fmoc-D-phenylalanine is an N-Fmoc-protected form of D-Phenylalanine (P319410). D-Phenylalanine is an essential amino acid that serves as a primary precursor for the biosynthesis of catecholamines in the body. D-Phenylalanine is also known to antagonize stress-induced analgesia in humans, and also acts as an anti-enkephalinase agent. | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis |
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