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1020567-30-9

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1020567-30-9 Structure

1020567-30-9 Structure
IdentificationBack Directory
[Name]

GSK-2324
[CAS]

1020567-30-9
[Synonyms]

GSK-2324
[Molecular Formula]

C29H22Cl2N2O4
[MOL File]

1020567-30-9.mol
[Molecular Weight]

533.4
Chemical PropertiesBack Directory
[Boiling point ]

698.1±55.0 °C(Predicted)
[density ]

1.351±0.06 g/cm3(Predicted)
[pka]

1.21±0.30(Predicted)
Hazard InformationBack Directory
[Description]

GSK2324 is a FXR agonist (EC50 = 50 nM, 102% efficacy).
[Uses]

GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively[1].
[References]

[1] Jonathan Y Bass, et al. Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13. DOI:10.1016/j.bmcl.2010.12.089
Spectrum DetailBack Directory
[Spectrum Detail]

GSK-2324(1020567-30-9)1HNMR
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