| Identification | Back Directory | [Name]
Benzenepropanoic acid, 3-[(3E)-1-[[(4-bromophenyl)methoxy]imino]ethyl]-α-ethoxy-, (αR)- | [CAS]
1033781-20-2 | [Synonyms]
Benzenepropanoic acid, 3-[(3E)-1-[[(4-bromophenyl)methoxy]imino]ethyl]-α-ethoxy-, (αR)- | [Molecular Formula]
C20H22BrNO4 | [MOL File]
1033781-20-2.mol | [Molecular Weight]
420.3 |
| Chemical Properties | Back Directory | [Boiling point ]
552.6±60.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [form ]
Liquid | [pka]
3.50±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity[1][2]. | [References]
[1] Chun SK, et al. A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells. Biochem Biophys Res Commun. 2015;467(2):441-446. DOI:10.1016/j.bbrc.2015.09.103
[2] Jang J, et al. The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018;200:49-55. DOI:10.1016/j.lfs.2018.03.022 |
|
|