10399-13-0

Under nitrogen, cyclohexane bromide (5.96 g, 36.55 mmol) was added dropwise to a mixture of magnesium chips (0.87 g, 36.25 mmol) and iodine crystals in anhydrous diethyl ether, starting with 1 mL and adding the remainder after the reaction had started, while maintaining gentle reflux. The mixture was stirred at room temperature until all the magnesium was dissolved (1 h). The resulting cyclohexyl magnesium bromide solution was cooled to 0 °C. A solution of 2-methyl 2-oxo-2-phenylacetate (3.0 g, 18.29 mmol) in tetrahydrofuran (20 mL) was added dropwise. The reaction mixture was allowed to reach room temperature and stirred for 2 h.