| Chemical Properties | Back Directory | [Boiling point ]
549.2±50.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [pka]
13.68±0.40(Predicted) | [InChI]
InChI=1/C20H26O4/c1-11-12-4-7-20(16(11)22)14(8-12)19-6-3-5-18(2,10-24-17(19)23)13(19)9-15(20)21/h12-15,21H,1,3-10H2,2H3/t12-,13+,14-,15+,18-,19-,20+/s3 | [InChIKey]
XZYYWKVDXANEHM-URHIBSLWNA-N | [SMILES]
O=C1OC[C@@]2(CCC[C@]31[C@]2([H])C[C@@H](O)[C@]12CC[C@]([H])(C(=C)C1=O)C[C@@]32[H])C |&1:4,8,9,12,14,17,24,r| |
| Hazard Information | Back Directory | [Description]
NC043 is a novel inhibitor of Wnt/β-catenin signaling, binds directly to CARF through forming a covalent bond with the Cys-516 residue of CARF. | [Uses]
15-Oxospiramilactone is a diterpene derivative. 15-Oxospiramilactone can inhibit Wnt/β-catenin signaling and tumorigenesis of colon cancer cells[1]. | [References]
[1] Wang W, et al. A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res. 2011 May;21(5):730-40. DOI:10.1038/cr.2011.30 |
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