| Identification | More | [Name]
Clodinafop-propargyl | [CAS]
105512-06-9 | [Synonyms]
cga-184927
CLODINAFOP-PROPARGYL
CLODINAFOP-PROPARGYL ESTER
propynyl (r)-2-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy] phenoxy]propanoate
Topik
CLODINAFOP-PROPARGYL PESTANAL
Propanoic acid, 2-4-(5-chloro-3-fluoro-2-pyridinyl)oxyphenoxy-, 2-propynyl ester, (2R)-
clodinafop-propargyl ester (bsi, pa e-iso)
Clodinafopacid
(R)-2-[4-[(5-Chloro-3-fluoro-2-pyridinyl)oxy]phenoxy]propionic acid 2-propynyl ester
Prop-2-ynyl (2R)-2-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenoxy]propanoate | [Molecular Formula]
C17H13ClFNO4 | [MDL Number]
MFCD01632328 | [Molecular Weight]
349.74 | [MOL File]
105512-06-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
48-57°C | [alpha ]
D20 +45.4° (c = 2 in acetone) | [Boiling point ]
432.7±45.0 °C(Predicted) | [density ]
1.37 g/cm3(Temp: 22 °C) | [storage temp. ]
0-6°C | [solubility ]
DMSO: 100 mg/mL (285.93 mM) | [form ]
neat | [pka]
-1.54±0.32(Predicted) | [color ]
Off-white to yellow | [BRN ]
8857008 | [Henry's Law Constant]
3.6×103 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) | [Major Application]
agriculture
environmental | [InChI]
InChI=1S/C17H13ClFNO4/c1-3-8-22-17(21)11(2)23-13-4-6-14(7-5-13)24-16-15(19)9-12(18)10-20-16/h1,4-7,9-11H,8H2,2H3/t11-/m1/s1 | [InChIKey]
JBDHZKLJNAIJNC-LLVKDONJSA-N | [SMILES]
C(OCC#C)(=O)[C@H](OC1=CC=C(OC2=NC=C(Cl)C=C2F)C=C1)C | [CAS DataBase Reference]
105512-06-9(CAS DataBase Reference) | [EPA Substance Registry System]
105512-06-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS07,GHS08,GHS09 | [Signal word ]
Warning | [Hazard statements ]
H302+H332-H373-H410 | [Precautionary statements ]
P260-P264-P273-P301+P312-P304+P340+P312-P314 | [Hazard Codes ]
Xn;N,N,Xn | [Risk Statements ]
R20/22:Harmful by inhalation and if swallowed .
R43:May cause sensitization by skin contact.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2811 | [WGK Germany ]
3 | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Skin Sens. 1
STOT RE 2 | [Hazardous Substances Data]
105512-06-9(Hazardous Substances Data) | [Toxicity]
LD50 in rats (mg/kg): 1829 orally; >2000 dermally; LC50 in rats (4 hr): >2325 mg/m3 by inhalation (Amrein) |
| Hazard Information | Back Directory | [Description]
Clodinafop-propargyl is a foliar-absorbed aryloxyphenoxypropionate herbicide which has the capacity to inhibit the lipid biosynthesizing enzyme, acetyl coenzyme-A-carboxylase.
Clodinafop-propargyl is a member of the Oxyphenoxy acid ester chemical class, which includes the active ingredients fluazifop-butyl, fenoxaprop-ethyl, diclofop methyl, quizalofop-ethyl and haloxyfop-methyl. | [Chemical Properties]
Pure Clodinafop-propargyl is colorless crystal, vapor pressure (25℃)3.19×10-3mPa, Solubility (25℃): water 4.0mg/L, ethyl alcohol 97 mg/L, acetone 880 mg/L, methyl benzene 690mg/L, n-hexane 0.0086 mg/L. Distribution coefficient (octane/water): KOWlogP=3.9(25℃). Clodinafop-propargyl can inhibit the synthesis of ester-like biology. It can be used to control amur foxtail, oat grass, avena sterilis, green bristlegrass and other weeds. | [Uses]
Herbicide. | [Uses]
Herbicides for weed control in wheat. | [Definition]
ChEBI: A carboxylic ester resulting from the formal condensation of the carboxy group of clodinafop with the hydroxy group of prop-2-yn-1-ol. It is widely used as a herbicide for the control of annual grass weeds in cereal crops. | [Production Methods]
The commercial production of clodinafop-propargyl involves a multi-step synthesis that centres on forming the active herbicidal ester from its precursor compounds. The process typically begins with the preparation of the chiral acid intermediate, (R)-2-[4-(5-chloro-3-fluoropyridin-2-yloxy)phenoxy]propanoic acid, which is then esterified with propargyl alcohol to yield clodinafop-propargyl. This reaction is carried out under controlled conditions using suitable catalysts and solvents to ensure high yield and enantiomeric purity, as only the R-enantiomer is biologically active. | [Mode of action]
Clodinafop-propargyl is to inhibit the activity of acetyl-CoA carboxylase in plants. It is a systemic conductive herbicide, absorbed by the leaves and sheaths of plants, transmitted by phloem, and accumulated in meristems of plants. In this case, acetyl-CoA carboxylase is inhibited, and fatty acid synthesis is stopped. So cell growth and division cannot proceed normally, and lipid-containing structures such as membrane systems are destroyed, leading to plant death. | [Toxicity evaluation]
a) Mammalian toxicity : WHO Classification : Class III slightly hazardous”
b) Environmental toxicity : It is non-toxic to fish, birds and bees.
Shelf life :Two years under normal storage conditions (Tech grade and Formulation) | [Pesticide Type]
Herbicide |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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