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1088991-95-0

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1088991-95-0 Structure

1088991-95-0 Structure
IdentificationBack Directory
[Name]

DORA-22
[CAS]

1088991-95-0
[Synonyms]

DORA-22
[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE
[Molecular Formula]

C23H22F2N4O2
[MOL File]

1088991-95-0.mol
[Molecular Weight]

424.44
Chemical PropertiesBack Directory
[Boiling point ]

524.3±50.0 °C(Predicted)
[density ]

1.258±0.06 g/cm3(Predicted)
[pka]

1.54±0.22(Predicted)
Hazard InformationBack Directory
[Description]

DORA-22 is an orexin receptor antagonist.
[Uses]

DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia[1][2].
[References]

[1] Gamble MC, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model. Sleep. 2020;43(3):zsz241. DOI:10.1093/sleep/zsz241
[2] Lin Y, Ret al. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice. Front Pharmacol. 2023;14:1138666. Published 2023 Apr 19. DOI:10.3389/fphar.2023.1138666
Spectrum DetailBack Directory
[Spectrum Detail]

DORA-22(1088991-95-0)1HNMR
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