110429-45-3

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110429-45-3 Structure

Identification	Back Directory
[Name] Triethylene Glycol 2-Bromoethyl Methyl Ether
[CAS] 110429-45-3
[Synonyms] mPEG4-Br m-PEG4-bromo m-PEG4-bromide Br-(CH2CH2O)4-Me Bromo-PEG4-methoxy Methyl-PEG4-bromide 1-Bromo-3,6,9,12-tetraoxatridecane 13-Bromo-2,5,8,11-tetraoxatridecane 2,5,8,11-Tetraoxatridecane, 13-bromo- Triethylene Glycol 2-Bromoethyl Methyl Ether 2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 1-Bromo-3,6,9,12-tetraoxatridecane
[Molecular Formula] C9H19BrO4
[MDL Number] MFCD12545963
[MOL File] 110429-45-3.mol
[Molecular Weight] 271.149

Chemical Properties	Back Directory
[Boiling point ] 296.3±25.0 °C(Predicted)
[density ] 1.256±0.06 g/cm3(Predicted)
[refractive index ] 1.4620 to 1.4660
[storage temp. ] 2-8°C
[form ] clear liquid
[color ] White to Yellow to Green
[CAS DataBase Reference] 110429-45-3

Safety Data	Back Directory
[HS Code ] 2909.19.6000

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[Description]

m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

[Biological Activity]

Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.

[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Cleavable

PEGs

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