| Identification | Back Directory | [Name]
Propargyl-PEG3-Tos | [CAS]
1119249-30-7 | [Synonyms]
Propargyl-PEG3-Tos
2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate
Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-(4-methylbenzenesulfonate) | [Molecular Formula]
C14H18O5S | [MDL Number]
MFCD20134051 | [MOL File]
1119249-30-7.mol | [Molecular Weight]
298.35 |
| Chemical Properties | Back Directory | [form ]
Oil | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C14H18O5S/c1-3-8-17-9-10-18-11-12-19-20(15,16)14-6-4-13(2)5-7-14/h1,4-7H,8-12H2,2H3 | [InChIKey]
XOLBARIQCXNLPS-UHFFFAOYSA-N | [SMILES]
C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCOCC#C |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG3-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. | [Uses]
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1]. Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781 |
|
|