| Identification | Back Directory | [Name]
Propargyl-PEG4-methylamine | [CAS]
1807530-11-5 | [Synonyms]
Alkyne-PEG4-MEA
PROPARGYL-PEG4-MEA
Propargyl-PEG4-methylamine
3,6,9,12-Tetraoxapentadec-14-yn-1-amine, N-methyl- | [Molecular Formula]
C12H23NO4 | [MDL Number]
MFCD28976683 | [MOL File]
1807530-11-5.mol | [Molecular Weight]
245.32 |
| Chemical Properties | Back Directory | [Boiling point ]
317.1±32.0 °C(Predicted) | [density ]
1.002±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [pka]
9.52±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-methylamine is a PEG linker that can be react with azide compounds in copper catalyzed azide-alkyne Click Chemistry reactions. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The PEG spacer increases hydrophilicity of the linker in aqueous environment. | [Uses]
Propargyl-PEG4-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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