| Identification | Back Directory | [Name]
Propargyl-PEG4-thiol | [CAS]
1347750-80-4 | [Synonyms]
SH-PEG4-ALKYNE
CAS_1347750-80-4
HC≡C-CH2-PEG4-SH
ALKYNE-PEG4-THIOL
Propyne-PEG4-thiol
Propargyl-PEG4-thiol | [Molecular Formula]
C11H20O4S | [MDL Number]
MFCD29764343 | [MOL File]
1347750-80-4.mol | [Molecular Weight]
248.34 |
| Chemical Properties | Back Directory | [Boiling point ]
332.9±37.0 °C(Predicted) | [density ]
1.064±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
9+-.0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. | [Biological Activity]
Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| Non-cleavable < span> | PEGs | |
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