| Identification | Back Directory | [Name]
N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide | [CAS]
1124381-43-6 | [Synonyms]
MSC-2032964A
N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide
N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
3-Pyridinecarboxamide, N-[5-(cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]- | [Molecular Formula]
C16H13F3N6O | [MDL Number]
MFCD30182335 | [MOL File]
1124381-43-6.mol | [Molecular Weight]
362.309 |
| Hazard Information | Back Directory | [Uses]
MSC 2032964A acts as a selective ASK1 inhibitor suppressing neuroinflammation in mice. | [in vivo]
MSC 2032964A (5 mg/kg, p.o.) exhibits an oral bioavailability of 82%, a clearance of 1.1 L/kg/ h, a half-life of 5.2 h and a volume of distribution Vss of 1.0 L/kg in SPrague Dawley rats[1].
MSC 2032964A (30 mg/kg, p.o., once daily for 40 days) attenuates neurological symptoms in both spinal cord and optic nerve lesions, and thus ameliorates the MOG (35-55) (HY-P1240)-induced autoimmune encephalomyelitis in C57BL/6J mice model[1]. | Animal Model: | MOG (35-55)-induced autoimmune encephalomyelitis in C57BL/6J mice[1] | | Dosage: | 30 mg/kg | | Administration: | p.o., once daily for 40 days | | Result: | Reduced demyelination in optic nerve, decreased astrocyte and microglia activation in spinal cord. |
| [IC 50]
ASK1: 96 nM (IC50) | [storage]
Store at -20°C |
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