| Identification | More | [Name]
3-Hydroxy-4-methoxyphenylacetic acid | [CAS]
1131-94-8 | [Synonyms]
3-HYDROXY-4-METHOXYPHENYLACETIC ACID
HOMOISOVANILLIC ACID
2-(3-hydroxy-4-methoxy-phenyl)acetic acid
Isohomovanillic acid | [EINECS(EC#)]
670-463-7 | [Molecular Formula]
C9H10O4 | [MDL Number]
MFCD00016829 | [Molecular Weight]
182.17 | [MOL File]
1131-94-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
127-132 °C | [Boiling point ]
371.3±27.0 °C(Predicted) | [density ]
1.307±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.36±0.10(Predicted) | [color ]
Pale Beige | [InChI]
1S/C9H10O4/c1-13-8-3-2-6(4-7(8)10)5-9(11)12/h2-4,10H,5H2,1H3,(H,11,12) | [InChIKey]
BWXLCOBSWMQCGP-UHFFFAOYSA-N | [SMILES]
COc1ccc(CC(O)=O)cc1O | [CAS DataBase Reference]
1131-94-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
22-36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
29189900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Beige Solid | [Uses]
3-Hydroxy-4-methoxyphenylacetic acid is a 4-O-methylated metabolite of catechol amines in man. 3-Hydroxy-4-methoxyphenylacetic acid is also a metabolite of 3,4-dihydroxyphenylalanine (DOPA) analogues as well as a metabolite of Hydroxytyrosol (H977000). | [Definition]
ChEBI: A monocarboxylic acid that is the 4-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 49, p. 2061, 1984 DOI: 10.1021/jo00185a061 | [Synthesis]
General procedure for the synthesis of 3-hydroxy-4-methoxyphenylacetic acid from 3-bromo-4-methoxyphenylacetic acid: sodium hydroxide (24.5 g, 612 mmol) and copper sulfate pentahydrate (1.02 g, 4.08 mmol) were added to a 125 mL sealed tube, followed by the addition of water (60 mL) to dissolve. The mixture was cooled and 3-bromo-4-methoxyphenylacetic acid (10 g, 40.8 mmol) was added. The reaction tube was sealed and placed in an oil bath at 150°C with stirring for 20 hours. After completion of the reaction, it was cooled to room temperature and the pH was adjusted slowly and dropwise to 3 by adding concentrated hydrochloric acid.The reaction mixture was filtered by pumping and the filter cake was washed with water. The collected solid was purified by column chromatography (eluent: dichloromethane/methanol, 30:1, v/v) to give an off-white solid product (3.3 g, 44.4% yield). | [IC 50]
Human Endogenous Metabolite | [References]
[1] Journal of Organic Chemistry, 1984, vol. 49, # 11, p. 2061 - 2063
[2] Synthesis, 2011, # 2, p. 217 - 222
[3] Patent: WO2010/75469, 2010, A1. Location in patent: Page/Page column 115
[4] Patent: US2011/9628, 2011, A1. Location in patent: Page/Page column 37
[5] Patent: CN105481849, 2016, A. Location in patent: Paragraph 0461; 0465; 0466 |
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