| Identification | Back Directory | [Name]
3-acetyl-8-bromo-5-chloro-2-(4-chloroanilino)-1H-quinolin-4-one | [CAS]
1151813-61-4 | [Synonyms]
KSI-3716
3-acetyl-8-bromo-5-chloro-2-(4-chloroanilino)-1H-quinolin-4-one
4(1H)-Quinolinone, 3-acetyl-8-bromo-5-chloro-2-[(4-chlorophenyl)amino]- | [Molecular Formula]
C17H11BrCl2N2O2 | [MDL Number]
MFCD28963891 | [MOL File]
1151813-61-4.mol | [Molecular Weight]
426.09 |
| Chemical Properties | Back Directory | [Boiling point ]
532.8±50.0 °C(Predicted) | [density ]
1.675±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (11.73 mM) | [form ]
Solid | [pka]
-2.74±0.20(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Uses]
KSI-3716 is a potent c-Myc inhibitor that blocks c-MYC/MAX binding to target gene promoters. KSI-3716 is an effective intravesical chemotherapy agent for bladder cancer[1]. | [in vivo]
Intravesical instillation of KSI-3716 at a dose of 5 mg/kg significantly suppresses tumor growth with minimal systemic toxicity[1]. | [References]
[1] Jeong KC, et al. Intravesical instillation of c-MYC inhibitor KSI-3716 suppresses orthotopic bladder tumor growth. J Urol. 2014 Feb;191(2):510-8. DOI:10.1016/j.juro.2013.07.019 |
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