| Identification | Back Directory | [Name]
1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin | [CAS]
1160247-92-6 | [Synonyms]
VU 0238429
1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
1-(4-Methoxy-benzyl)-5-trifluoromethoxy-1H-indole-2,3-dione
1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
1H-Indole-2,3-dione, 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)- | [Molecular Formula]
C17H12F3NO4 | [MDL Number]
MFCD16618396 | [MOL File]
1160247-92-6.mol | [Molecular Weight]
351.28 |
| Chemical Properties | Back Directory | [Boiling point ]
459.7±55.0 °C(Predicted) | [density ]
1.432±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
-3.68±0.20(Predicted) | [color ]
orange | [InChI]
1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3 | [InChIKey]
CKLGZXFOLMHCMC-UHFFFAOYSA-N | [SMILES]
COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
36-50/53 | [Safety Statements ]
26-60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
VU 0238429 is a selective positive allosteric modulator of M5 receptors. | [Biological Activity]
VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimerμs disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4. | [IC 50]
mAChR5 | [storage]
Store at -20°C |
|
| Company Name: |
Twochem Co.Ltd.
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| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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