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1246086-78-1

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1246086-78-1 Structure

1246086-78-1 Structure
IdentificationBack Directory
[Name]

VU 0364439
[CAS]

1246086-78-1
[Synonyms]

CS-629
VU 0364439
VU 0364439 10MG
VU 0364439, >=98%
VU0364439/VU-0364439
VU 0364439 USP/EP/BP
VU 0364439;VU0364439; VU-0364439
N-(3-Chloro-4-(N-(2-chlorophenyl)sulfamoyl)phenyl)picolinamide
N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide
2-PyridinecarboxaMide, N-[3-chloro-4-[[(2-chlorophenyl)aMino]sulfonyl]phenyl]-
N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide VU0364439
[Molecular Formula]

C18H13Cl2N3O3S
[MDL Number]

MFCD22378484
[MOL File]

1246086-78-1.mol
[Molecular Weight]

422.285
Chemical PropertiesBack Directory
[density ]

1.538±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

≥21.11 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
[form ]

solid
[pka]

7.71±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
Hazard InformationBack Directory
[Uses]

VU 0364439 is a mGlu4 positive allosteric modulator (PAM) (1,2).
[IC 50]

mGlu4 Receptor: 19.8 nM (EC50)
[storage]

Store at -20°C
[References]

[1]. lucyna pomierny-chamio?o, kinga rup, bartosz pomierny, et al. metabotropic glutamatergic receptors and their ligands in drug addiction. pharmacology & therapeutics, 2014, 142:281-305.
[2]. albert j. robichaud, darren w. engers, craig w. lindsley, et al. recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as cns therapeutics. acs chemical neuroscience, 2011, 2:433-449.
[3]. colleen m. niswender, kari a. johnson, c. david weaver, et al. discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. mol. pharmacol., 2008, 74(5):1345-1358.
[4]. darren w. engers, patrick r. gentry, richard williams, et al. synthesis and sar of novel, 4-(phenylsulfamoyl)phenylacetamide mglu4 positive allosteric modulators (pams) identified by functional high-throughput screening (hts). bioorg. med. chem. lett., 2010, 20:5175-5178.
Spectrum DetailBack Directory
[Spectrum Detail]

VU 0364439(1246086-78-1)1HNMR
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